
Today on Drug Discovery & Development
Label update broadens Camzyos reach in obstructive HCM, trims echo burden for stable patients
The FDA has approved a sweeping label update for Bristol Myers Squibb’s Camzyos (mavacamten), the first‑and‑only FDA‑approved cardiac myosin inhibitor for adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Until Camzyos reached the market in 2022, physicians mainly relied on beta‑blockers, calcium‑channel blockers, disopyramide or invasive septal‑reduction surgery to relieve outflow obstruction. The latest update lets…Pharma 50 Deep Dive: Oncology leads with $110B in sales; GLP-1s continue surge
With the $30B Keytruda franchise leading, Oncology maintained its top position among the top 50 drugs in FY2024, but significant shifts occurred across therapeutic areas. Metabolic Diseases saw major growth, as GLP-1 agonists like Ozempic (+26%), Mounjaro (+124%), and Wegovy (+86%) reshaped the diabetes and obesity markets. Landmark trials from late 2023 to present also…Drug Discovery and Development See More >

How a ‘rising tide’ of inclusivity is transforming clinical trials
Let’s say there’s a Black female patient with an aggressive form of breast cancer. She meets with her oncologist to discuss a promising targeted therapy that recently won FDA approval. The drug showed strong efficacy in clinical trials, with a 65% response rate. Yet when she asks about efficacy data specific to Black women, she…
Mary Marcus appointed CEO of NewAge Industries

Biotech in 2025: Precision medicine, smarter investments, and more emphasis on RWD in clinical trials

External comparator studies: What researchers need to know to minimize bias

Tiny breaths, big impacts: Bridging the gap between laboratory discoveries and clinical applications in breath research with mouse models
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Spatial biology: Transforming our understanding of cellular environments
Spatial biology is revolutionizing our understanding of how cells interact with their natural environments. Although that may sound like an overstatement, it isn’t. Spatial biology involves the use of advanced imaging and molecular techniques to visualize and map the location of cells, transcripts, proteins and their interactions within tissues. Traditional biological studies have long focused…

Biotech in 2025: Precision medicine, smarter investments, and more emphasis on RWD in clinical trials

Genomics in 2025: How $500 whole genome sequencing could democratize genomic data

St. Jude pioneers gene editing and structural biology to advance pediatric research
![A display of DNA sequencing output from an automated ABI 373 sequencer. [National Human Genome Research Institute (NHGRI)]](https://www.drugdiscoverytrends.com/wp-content/uploads/2024/06/51187236177_b7b566a401_k-268x170.jpg)
Helix and Recursion join forces in quest to crack the AI-driven drug discovery code
Infectious Disease See More >

Pregnancy associated with less long COVID: Researchers call for studies on protective biology
A recent study published this week, on April 1, 2025, found that pregnant women with SARS-CoV-2 infection may have a lower risk of developing long COVID compared to non-pregnant women. This finding, detailed in Nature Communications, shed light on pregnancy’s protective effects. The large-scale retrospective study, conducted under the guidance of researchers from Weill Cornell…

How technology advances are helping scientists unlock the mysteries of zoonotic diseases

Advances in next generation vaccine development for SARS-CoV-2

World AIDS Day Summit & Celebration slated for early December

Moderna and Pfizer win approval for KP.2 vaccine as KP.3 variants account for about half of current cases
Oncology See More >

Cellares and UW-Madison partner to automate manufacturing for novel solid tumor CAR-T
Cell therapies hold immense promise but, traditionally, carry a similarly large price tag often linked to complex, manual manufacturing. In its latest move to help make these life-saving and -enhancing treatments more scalable and potentially accessible, Cellares is partnering with the University of Wisconsin School of Medicine and Public Health to automate the clinical-scale manufacturing…

Why smaller, simpler molecular glues are gaining attention in drug discovery

COTA Healthcare announces AI milestone in real-world oncology data

Flatiron Health sees shift from “what if” to “what is” in real-world evidence in oncology
