Drug Discovery and Development

Let’s say there’s a Black female patient with an aggressive form of breast cancer. She meets with her oncologist to discuss a promising targeted therapy that recently won FDA approval. The drug showed strong efficacy in clinical trials, with a 65% response rate. Yet when she asks about efficacy data specific to Black women, she…

Spatial biology is revolutionizing our understanding of how cells interact with their natural environments. Although that may sound like an overstatement, it isn’t.  Spatial biology involves the use of advanced imaging and molecular techniques to visualize and map the location of cells, transcripts, proteins and their interactions within tissues. Traditional biological studies have long focused…

A recent study published this week, on April 1, 2025, found that pregnant women with SARS-CoV-2 infection may have a lower risk of developing long COVID compared to non-pregnant women. This finding, detailed in Nature Communications, shed light on pregnancy’s protective effects. The large-scale retrospective study, conducted under the guidance of researchers from Weill Cornell…

AP Biosciences is building the protocol around one key objective: confirm that conditional CD137 agonism, a tumor-restricted T-cell costimulation, can be delivered safely in patients whose HER2-positive solid tumors express the p95HER2 variant, a truncated, drug-resistant form of HER2. To that end, it recently dosed the first patient in the Phase 1/2 trial of its…