Biochemists Discover Cause of Genome Editing Failures With Hyped CRISPR System
Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, and sometimes add a…
Genome Editing Reduces Cholesterol in Large Animal Model, Laying Human Trial Groundwork
Gene-Editing Technique Cures Genetic Disorder in Utero
Precision Genomics Point the Way to Mutations Associated With Accelerated Aging
CRISPR Editing Reduces Repetitive Behavior in Mice With a Form of Autism
Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder. Employing gold nanoparticles to deliver the DNA-cutting Cas9 enzyme into the brain—a technique developed at the University of California, Berkeley, and called CRISPR-Gold—the researchers were…
Genomics Offers New Treatment Options for Infants with Range of Soft Tissue Tumors
Gene Editing Just Got Easier
Genomic Medicine May One Day Revolutionize Cardiovascular Care
Genome Editing Method Targets AIDS Virus
International Consortium Wants to Sequence the DNA of 1.5 Million Species
Using Proteomics to Understand Pathogens
Gene Disruption Signals Cerebral Palsy and Autism Link
Scientists Use CRISPR to Improve Cacao Trees, Key to Chocolate
Use of the powerful gene-editing tool CRISPR-Cas9 could help to breed cacao trees that exhibit desirable traits such as enhanced resistance to diseases, according to Penn State plant scientists. The cacao tree, which grows in tropical regions, produces the cocoa beans that are the raw material of chocolate. Reliable productivity from cacao plants is essential…
Study Discovers New Molecular Mechanism Likely Involved in Cancer Metastasis
Cancer is most devastating when it metastasizes–when tumor cells break away, travel through the bloodstream, and then attach elsewhere, only to grow another tumor. A significant amount of scientific research has focused on finding ways to prevent metastasis. For some time, scientists have understood that a particular biochemical pathway, known as the PDK1 pathway, is…
New Biotech Technique Accelerates Protein Therapy Research
New CRISPR Technology ‘Knocks Out’ Yeast Genes with Single-Point Precision
The CRISPR-Cas9 system has given researchers the power to precisely edit selected genes. Now, researchers have used it to develop a technology that can target any gene in the yeast Saccharomyces cerevisiae and turn it off by deleting single letters from its DNA sequence. Such genome-scale engineering – in contrast to traditional strategies that only target a…
Gene Therapy for Lipoprotein Lipase Deficiency Yields Promising Results
CRISPR/Cas9 Silences Gene Associated With High Cholesterol
Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment. This marks the first time researchers have delivered CRISPR/Cas9 repressors for targeted therapeutic gene…
Researchers Use CRISPR to Edit DNA Outside of the Cell for the First Time
Scientists at Christiana Care Health System’s Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal. Investigators…
AACR 2018: St. Jude Partners With Microsoft to Create Global Genomic Database for Pediatric Cancer
Researchers around the globe can now access thousands of pediatric cancer genomic datasets, thanks to a new cloud-based initiative. The St. Jude Children’s Research Hospital has launched the St. Jude Cloud—an online, publicly available data-sharing and collaboration platform—that gives researchers the world’s largest public repository of pediatric cancer genomics data. Scott Newman, PhD, group lead…
AACR 2018: How Do Melanoma Cells Survive Drug Treatment Long Enough to Acquire Drug Resistance?
Breakthrough Brings Gene-Editing Medicine One Step Closer to Patient Applications
Imagine a future where a guided biomachine put into your body seeks out defective gene sequences in each cell and edits in the correct information with precision accuracy. It’s called gene editing, and University of Alberta researchers have just published a game-changing study that promises to bring the technology much closer to therapeutic reality. “We’ve…