For years, many small-molecule teams have treated comprehensive Absorption, Distribution, Metabolism and Excretion (ADME) profiling as a lead-optimization step. That is, it serves as a place to spend heavily once a lead series has already emerged. Now, Ginkgo Datapoints, Tangible Scientific and Inductive Bio are betting that AI, automation and tighter compound logistics can move…
How to tackle the unique pharmacokinetic properties of covalent drugs
Covalent drugs have been a transformative medical advancement since aspirin was first approved in 1899. Penicillin followed soon after and is one of the most impactful pharmaceutical breakthroughs in human history. Since around a decade ago, an increasing number of new covalent drugs have been approved for a wide range of conditions, bringing hope to…