
HIV/AIDS Research Yields Dividends Across Medical Fields
EXP2 Protein Helps Deadliest Malaria Protein Obtain Nutrients During Infection
NIH Begins Clinical Trial of Live, Attenuated Zika Vaccine
Two Diabetes Medications Don’t Slow Progression of Type 2 Diabetes in Youth
HIV Vaccine Elicits Antibodiess in Animals That Neutralize Dozens of HIV Strains
An experimental vaccine regimen based on the structure of a vulnerable site on HIV elicited antibodies in mice, guinea pigs and monkeys that neutralize dozens of HIV strains from around the world. The findings were reported today in the journal Nature Medicine by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part…
Most Women with Early Breast Cancer Do Not Benefit From Chemotherapy
New findings from the groundbreaking Trial Assigning Individualized Options for Treatment (Rx), or TAILORx trial, show no benefit from chemotherapy for 70 percent of women with the most common type of breast cancer. The study found that for women with hormone receptor (HR)-positive, HER2-negative, axillary lymph node–negative breast cancer, treatment with chemotherapy and hormone therapy…
Essential Malaria Parasite Genes Revealed
Researchers have exploited a quirk in the genetic make-up of the deadly malaria parasite, Plasmodium falciparum, to create 38,000 mutant strains and then determine which of the organism’s genes are essential to its growth and survival. P. falciparum is responsible for about half of all malaria cases and 90 percent of all malaria deaths. New…
NIH Announces National Enrollment Date for All of Us Research Program to Advanced Precision Medicine
Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye
High Exposure to Radiofrequency Radiation Linked to Tumor Activity in Male Rats
High exposure to radiofrequency radiation (RFR) in rodents resulted in tumors in tissues surrounding nerves in the hearts of male rats, but not female rats or any mice, according to draft studies from the National Toxicology Program (NTP). The exposure levels used in the studies were equal to and higher than the highest level permitted…
RSV Vaccine Enters Clinical Testing
A Phase 1 clinical trial to test the safety and tolerability of an investigational vaccine against respiratory syncytial virus (RSV) has begun at the National Institutes of Health Clinical Center in Bethesda, Maryland. The trial also will assess the vaccine’s ability to prompt an immune response in healthy adult participants. The investigational vaccine was developed…
Experimental Malaria Vaccine Offers Durable Protection Against Many Strains
4 Pivotal NIH-Funded Artificial Pancreas Research Efforts Begin
Epilepsy Drug Discovered in Fish Model Shows Promise in Small Pediatric Clinical Trial
“Bench-to-bedside” describes research that has progressed from basic science in animal models that has led to therapies used in patients. Now, a study in the journal Brain describes what could be considered a direct “aquarium-to-bedside” approach, taking a drug discovered in a genetic zebrafish model of epilepsy and testing it, with promising results, in a small number…
NIAID-Sponsored Study to Assess Shorter-Duration Antibiotics in Children
Study Finds Ebola Treatment Holds Promise, Although Results Not Definitive
NIH Begins Testing Investigational Zika Vaccine in Humans
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has launched a clinical trial of a vaccine candidate intended to prevent Zika virus infection. The early-stage study will evaluate the experimental vaccine’s safety and ability to generate an immune system response in participants. At least 80 healthy volunteers…