A research team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of Technology (MIT) has found that combining a specialized version of an antihypertension drug with immune checkpoint blockers could increase the effectiveness of cancer immunotherapies. As described in their report published in PNAS, the combination treatment significantly improved tumor response…
Insomnia-associated Gene Regions Suggest Underlying Mechanisms, Treatment Targets
Interaction Between Immune Factors Triggers Cancer-Promoting Chronic Inflammation
A Massachusetts General Hospital (MGH) research team has identified interaction between two elements of the immune system as critical for the transformation of a protective immune response into chronic, cancer-promoting inflammation. In their report published in PNAS, the investigators demonstrate that elevated levels of the immune factor IL-33 and regulatory T cells (Tregs), which suppress…
Study Reveals How Brain Tumors Escape the Effects of Antiangiogenic Drugs
Combination Drug Targeting Opioid System May Help Relieve Symptoms of Major Depression
Study Defines Mechanisms Behind Focused Ultrasound-assisted Treatment of Brain Tumors
MGH Team Defines the Mechanisms of Action of Key Genetic Abnormality in Ewing Sarcoma
A Massachusetts General Hospital (MGH) research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma – the second most common bone cancer in children and young adults – unleashes tumor growth. In their paper in the journal Genes & Development the researchers show that blocking the fusion protein…
Microfluidic System Incorporates Neuroinflammation Into ‘Alzheimer’s in a Dish’ Model
Building on their development of the first culture system to replicate fully the pathology behind Alzheimer’s disease, a Massachusetts General Hospital (MGH) research team has now produced a system that includes neuroinflammation, the key biological response that leads to the death of brain cells. The investigators describe their system, which incorporates the glial cells that…
