Swiss pharma giants Novartis and Roche consistently rank among the top pharma companies in terms of revenue. In 2024, the two companies are also leading in total international patent volume. Meanwhile, smaller firms like Incyte and Vertex Pharma are punching above their weight in market impact. For instance, Incyte, with a market cap of just…
Lilly shakes up obesity drug market with Zepbound self-pay price now up to 70% lower than the competition
GLP-1 therapies just got a whole lot less expensive for patients who pay out of pocket. Eli Lilly’s Zepbound (tirzepatide) single-dose vials are now available at rates similar to compounded versions of semaglutide. Patients can now access a four-week supply of Zepbound for as little as $399 for the 2.5 mg dose and $549 for…
Experts endorse MDMA-assisted therapy for PTSD amid FDA adcomm setback
A group of prominent researchers and clinicians have published a consensus statement backing the use of MDMA-assisted therapy for post-traumatic stress disorder (PTSD). This statement comes as FDA is reviewing a New Drug Application for midomafetamine (MDMA) for the condition. “On the basis of the safety and efficacy data we have seen, assuming the integrity…
Here’s where the biotech funding is going in 2023 and 2024
Over the past year, North American biotech firms continued to lear the world in funding by a significant margin in an analysis that included a various equity fundraising types drawn from Crunchbase. Argenx, a publicly traded Dutch biotech, raised $1.1 billion from investors in July 2023 through a global offering. Next in line was…
The pay gap: Best paid in pharma still not anywhere close to other industries
An analysis of 19 prominent pharma companies, including Johnson & Johnson, Pfizer, Lilly, Roche, Merck & Co. among others, revealed that the average stock return was 3.7% points in 2023. (Lilly was the best performing with a return of 59% while Moderna was the worst in the list with a return of –44%.) By…
Which metro areas and states have the most biopharma jobs?
The Greater Boston Area, New York City Metro and San Francisco Bay Area are the top three hubs for biopharma job listings based on an analysis of more than 1,700 recent job postings. Within these hubs, prominent job listing title examples include Vice President of Intellectual Property, Scientist (Bioassay) and Data Scientist I and Research…
Does biopharma R&D spending translate to results? It’s complicated
A recent review of financial data from 25 major pharmaceutical companies reveals an inconsistent relationship between R&D spending, revenue, and stock returns. The analysis, which included industry giants such as Merck, Pfizer, Johnson & Johnson, and AbbVie, among others, aimed to uncover potential correlations between these key performance indicators. The companies with the highest highest…
Top pharma companies ranked by 2023 R&D spend
[Updated with more comprehensive information on April 30, 2024] Which major pharmaceutical company leads the way in research and development? Data reveals that the top R&D spender in 2023 was Merck & Co., by a wide margin. While Pfizer had almost as much revenue as Merck ($60.1 billion vs. $58.5 billion), its R&D ratio was…
Are Big Pharma giants getting the right ROI on their R&D investments? A visual exploration
While annual reports show broadly similar R&D strategies among Merck & Co., Pfizer, Johnson & Johnson and AbbVie, their 2020–2023 financial metrics reveal a concerning trend. Merck & Co. may be the new top dog of Big Pharma, but the firm’s 1.4% revenue growth in 2023 represents a significant slowdown. Pfizer’s 41.7% revenue decline from…
Where are the top Big Pharma hubs in 2023?
By analyzing the financials of dozens of Big Pharma firms, we can pinpoint the global hubs that drive much of the industry’s innovation. This analysis reveals regions like New York, New Jersey, Tokyo, Basel, and Frankfurt metro area as core centers for pharma revenue and R&D spending. Unsurprisingly, the area with the densest concentration of…
A timeline of Aduhelm’s rise and fall
The story of Aduhelm has been rocky now for years. Biogen turned heads when its controversial Alzheimer’s therapy won accelerated approval from the FDA against the advice of its own advisory panel in mid-2021. The company had high hopes for the antibody at that point, pricing it at an average of $56,000 per year. Aduhelm…
Two-thirds of pharma companies plan to up IT investments in 2024, survey finds
Two out of three pharma companies (67%) plan to ramp up investment in IT, including AI, over the next 12 months, according to a survey from the cloud vendor Rackspace Technology and Dell/VMware conducted in October 2023. About the same amount, 68%, reported challenges in recruiting and hiring talent skilled in cloud and AI technology.…
Kristofer Mussar on VectorBuilder’s ethical imperative in gene delivery
As genetic technologies unlock new possibilities, companies like VectorBuilder aim to navigate progress responsibly, guided by a strong moral compass. “Ethics to me is the one thing that really is so, so important,” said Kristofer Mussar, managing director of VectorBuilder GmbH. “I have such a high ethical threshold I make decisions that are sometimes not…
Biotech boomtowns: Comparing salaries and cost of living in 9 global hotspots
Boston is arguably the top biotech hub in the U.S., but the salaries in San Francisco and New York City tend to be higher. According to recent data, the San Francisco area offers the top average salaries for biotech jobs, followed closely by New York City. But the cost of living in all three cities…
Eli Lilly’s Mounjaro sees explosive sales growth, yet demand outpaces supply
Eli Lilly’s diabetes medication Mounjaro (tirzepatide) is seeing explosive sales growth, jumping from $187.3 million in the third quarter of 2022 to $1.4 billion in the same period this year. Conversely, sales of Lilly’s Trulicity, another diabetes drug, have declined, dipping from $1.85 billion in Q3 2022 to $1.67 billion in Q3 2023. Mounjaro is…
How the latest AI executive order might impact drug development in the U.S.
The White House has released an executive order that contains what it hails as “the most sweeping actions ever taken to protect Americans from the potential risks of AI systems.” Relevant to drug development, a fact sheet on the order describes its aim to help further “the responsible use of AI in healthcare and the…
GLP-1 drug tirzepatide shines in SURMOUNT-3 trial with weight loss of 26.6%
In the phase 3 SURMOUNT-3 trial, tirzepatide recipients saw some of the most impressive weight loss results among trials of GLP-1 drugs, including most notably semaglutide. In the study, participants’ total mean weight loss was 26.6% over 84 weeks following a 12-week intensive lifestyle intervention and subsequent tirzepatide treatment. In all, participants who received tirzepatide…
10 major pharma and biotech companies that downsized in 2023
The biopharma industry faced mounting headwinds in 2023, with several major players announcing significant restructuring efforts. Faced with expiring patents, inflation and rising interest rates, and heightened FTC scrutiny, companies looked to trim expenses and refocus their businesses. The ebbing tied of the pandemic posed a challenge for a number of drug developers as well.…
At Day 21, low-dose ketamine KET01 shows no statistical edge over placebo
Ketabon GmbH revealed positive top-line results from its phase 2 KET01-02 study investigating KET01, an oral slow-release formulation of oral ketamine, for treatment-resistant depression (TRD). Results were promising initially. Investigators noted improvements in depression severity as early as day 4, but data were not statistically significant over placebo at day 21. A look at Ketabon…
Prices of top 25 Medicare Part D drugs more than doubled since market entry; AARP offers new insights in drug pricing report
Medicare Part D drug prices have seen a significant surge in recent years. The price of the arthritis drug Enbrel has soared 701% since its launch in 1998, and the diabetes drug Januvia has jumped 275% since its debut 2006. All in all, the average price increase for the 25 brand-name drugs with the highest…
Working backwards: AWS’s strategy for pharma’s cloud-enabled transformation
The meteoric rise of the AI sector is hard to fathom. Projections from Precedence Research suggest that the global AI market could balloon by 2600% from 2022 to 2032, hitting $1.87 trillion — an annual growth rate of 39%. In pharma, AI and data science demand is surging though overall growth is sluggish. Despite advances…
CGT demands vision, partnership and patient-centricity to transform healthcare
As personalized medicine continues to progress, cell and gene therapy (CGT) development is poised to enable tremendous medical breakthroughs. Unlike traditional treatments which merely manage symptoms, CGT could treat the root biological cause of many diseases: the faulty genes. “The cell and gene therapy space is truly exciting. What this ultimately means for patients and…
Amgen v. Sanofi: A Supreme Court decision steers drug developers into uncharted waters
The Supreme Court’s recent decision in the case of Amgen Inc. v. Sanofi (No. 21-757) could chart a new course for both the pharmaceutical industry and patent law. In this decision, the Supreme Court provided clarity on what the Patent Act means by ‘enablement,’ raising the bar for the level of detail needed in certain…
The big spenders: The top 25 pharma companies in R&D investments
In the throes of the COVID-19 pandemic, when the world was desperate for a lifeline, the global pharma sector’s R&D prowess was thrust into the limelight. Now, as the pandemic begins to loosen its grip, the sector continues to make aggressive investments in research and development (R&D). At the tip of the spear of this…
Navigating generative AI in drug discovery and data analysis: Seizing the opportunity and avoiding pitfalls
Along with predictive AI, generative AI is emerging as a promising tool in drug discovery. Thanks in part to the rise of ChatGPT, interest in the technology in drug discovery is on the upswing. In March, a preprint appeared examining the potential to use generative AI to enable de novo antibody design. Also this year,…