Researchers at the Broad Institute of MIT and Harvard have taken the Connectivity Map— a widely used resource of tools and data — to new heights with a massively scaled-up version. For this new platform, the researchers have also improved its accessibility for the scientific community, enabling studies of small molecule and gene function and informing…
Researchers Engineer CRISPR to Edit Single RNA Letters in Human Cells
The Broad Institute and MIT scientists who first harnessed CRISPR for mammalian genome editing have engineered a new molecular system for efficiently editing RNA in human cells. RNA editing, which can alter gene products without making changes to the genome, has profound potential as a tool for both research and disease treatment. In a paper…