Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Verona Starts COPD Trial

By Drug Discovery Trends Editor | July 13, 2012

Verona Pharma plc, the biotechnology company focused on developing novel treatments for chronic respiratory diseases, announces that it has commenced a new trial with its lead drug candidate, the dual PDE 3 and 4 inhibitor, RPL554.

This clinical trial is taking place at the Medicines Evaluation Unit (MEU) in Manchester, UK and is designed to test the anti-inflammatory properties of RPL554 in healthy subjects with respect to chronic obstructive pulmonary disease (“COPD”). The subjects will be treated once daily for 6 consecutive days with inhaled RPL554 before being challenged on the last day by an irritant agent that provokes an inflammatory response in their airways. The ability of RPL554 to reduce the amount of inflammation in the airways will be measured. This particular test resembles certain aspects of the airway inflammation in patients with COPD and is a common step in the development of new medicines for this disease. The study is a randomized, double-blind, placebo-controlled study that will enroll 24 subjects and is expected to finish around year-end.

Dr. Jan-Anders Karlsson, CEO of Verona Pharma said: “RPL554 has the potential to become a new targeted therapy for patients with severe forms of respiratory disease. This trial at MEU is important as it is the first clinical trial designed to evaluate specifically the anti-inflammatory properties of RPL554 in human subjects. RPL554 shows unique dual bronchodilator and anti-inflammatory properties in pre-clinical models, and the company has already demonstrated that RPL554 is a bronchodilator in patients with COPD and asthma. Today there is no therapy that combines both bronchodilator and anti-inflammatory properties in one compound available to patients with respiratory diseases.”

Date: July 9, 2012
Source: Verona Pharma plc


Filed Under: Drug Discovery

 

Related Articles Read More >

Sanders, King target DTC pharma ads but the industry worries more about threats to its $2B R&D model
Zoliflodacin wins FDA nod for treatment of gonorrhea
FDA approved ENFLONSIA for the prevention of RSV in Infants
First clinical study results of Dupixent for atopic dermatitis in patients with darker skin tones 
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE