Selexis SA, a global life sciences company for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins, announced that its US-based customer, Lubris LLC, has achieved over 1 g/L per liter yield in manufacturing production runs of LUB-13-04 as measured by Lubris’ CMO partner. LUB-13-04 is a proprietary construct of the recombinant human protein lubricin (Proteoglycan 4 protein, rLubricin) which is expressed from the SURE CHO-M cell line generated with the Selexis SUREtechnology Platform. LUB-13-04 is in pre-clinical development for dry eye syndrome and osteoarthritis.
Lubricin is a large endogenous complex glycoprotein composed of 40% carbohydrates, originally identified as a lubricating component of synovial fluid. While lubricin has been most actively evaluated for the treatment for osteoarthritis, it is also being studied in dry eye, dry mouth, surgical adhesions and other unmet medical needs.
“The results from the Selexis/Lubris partnership are quite impressive,” said Igor Fisch, PhD, CEO of Selexis SA. “We continue to demonstrate that the SUREtechnology Platform has a major impact on the economics of manufacturing biologics by significantly increasing the manufacturing cell line’s stability and productivity.”
“Recombinant lubricin has been proven to be difficult to express efficiently at levels that ensured commercial viability. This is the first reported case of expression levels exceeding 1 g/L for lubricin (or lubricin-like proteins). We chose Selexis based on its track record for overcoming expression bottlenecks with difficult-to-express proteins, and generating fully documented cell lines used for clinical manufacturing,” said Ed Truitt, CEO of Lubris. “These results represent a major development milestone as they demonstrate that our technology can be manufactured cost effectively in an increasingly challenging economic environment. We are on schedule to begin clinical trials in 2013 with our Swiss based European partner with our treatment for dry eye disease which represents a significant unmet medical need in a multi-billion dollar ophthalmic market.”
Date: June 27, 2012
Source: Selexis SA
Filed Under: Drug Discovery