Drugs don’t lead to sustainable alleviation of mental disorders, claim the psychologists Dr. Jürgen Margraf and Dr. Silvia Schneider in a commentary published in EMBO Molecular Medicine.
The researchers from Ruhr-Universität Bochum have compiled numerous studies that question the long-term effectiveness of psychotropic drugs; some even document negative effects after prolonged application. Psychotherapies, on the other hand, are effective in the long-term. The authors postulate that it is necessary to interlink the research into the biological, psychological and social factors, rather than reduce mental diseases to biological causes alone.
The currently available drugs cannot permanently alleviate the symptoms of mental disorders. This is the conclusion drawn by psychologists Margraf and Schneider
Effect of Drugs Are Only Short-Lived
Margraf and Schneider have compiled ample evidence suggesting that anti-depressant, anti-anxiety, and anti-ADHD drugs have only a short-term effect. If patients discontinue treatment, their symptoms return. The authors suspect that medication for the treatment of schizophrenia would yield similar results.
Long-term application of the drugs might even have a negative effect—for example, increased risk of a chronic illness or higher relapse quota.
Psychotherapies Are Not Available for Many Patients
According to the authors, psychotherapies such as cognitive behavioral therapy yield much better and more sustainable results in the long-term.
“The main problem with psychotherapy is not its effectiveness or costs,” says Schneider. “Rather, it is its insufficient availability.”
While psychotropic drugs can be applied straight away, patients often have to wait a long time for their first appointment with a therapist.
Biological Concepts Are Insufficient
In their article, the psychologists from Bochum also discuss the question why better therapies are still non-existent, despite 60 years of dedicated research. According to their opinion, one reason might be the ill-advised notion that mental disorders can be explained by biological concepts alone.
“Today, it has become standard to tell the patients and the public that mental disorders are caused by an imbalance in the neurotransmitter system,” said Margraf.
However, it is not yet clear if that phenomenon is the cause or the effect of the diseases. Social factors should not be neglected. According to Schneider and Margraf, the rigid categories of “ill” and “healthy” are not helpful at all with regard to mental disorders, which manifest in many different forms.
Fewer Psychotropic Drugs, More Psychotherapy
The authors postulate that it is necessary to link research into the biological, psychological, and social factors and to broaden the narrow view of possible biological causes. Large pharmaceutical companies should reduce the marketing of psychotropic drugs. Moreover, patients should be given access to psychotherapeutic services more quickly.
- Jürgen Margraf, Silvia Schneider. “From neuroleptics to neuroscience and from Pavlov to psychotherapy: more than just the ‘emperor’s new treatments’ for mental illnesses?” EMBO Molecular Medicine. 2016. e201606650. DOI: 10.15252/emmm.201606650.
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Filed Under: Drug Discovery