Malvern’s Zetasizer µV is an advanced light scattering system for the characterization of proteins and other biomolecules.
The system supports optimizing sample and storage conditions; verifying the quaternary structure of protein complexes; identifying thermal characteristics; and assessing protein solubility and sample purity.
The Zetasizer µV requires just two microliters of sample. The sample is recoverable, ensuring no loss of valuable material. The Zetasizer µV employs both dynamic (DLS) and static light scattering (SLS).
In drug target development, dynamic and static light scattering in combination can help in optimizing crystallization conditions, speeding up the development process. In protein therapeutics, DLS provides a sensitive method for aggregate detection, improving the success of a purification procedure or providing a tool for monitoring the early stages of instability.
Published in Drug Discovery & Development magazine: Vol. 11, No. 11, November, 2008, p.36.
Filed Under: Drug Discovery