The Uniqsis FlowSyn flow chemistry system has an upgraded pump manifold that continuously monitors each high pressure reagent channel and alerts the user to any flow abnormalities, saving time and reagents by preventing experiments from continuing under erroneous conditions.
Reagent immiscibility, incomplete wetting of pump components, or the presence of static or transient air bubbles are the usual causes of the flow irregularities that occur during a run. In most cases, the problem can be corrected by re-priming the pump, aborting the experiment.
With the reagent manifold used in FlowSyn, the pump can be re-primed on the fly, so that the run can continue. Interlocks are provided so that if the error is not remedied within a specified period, the experiment is aborted. If an error condition is detected in one pump channel, the other is automatically stopped simultaneously until the problem is addressed.
New automatic injection valves with specially designed, highly inert rotor seals and larger diameter channels allow sample loops to be filled more quickly and are less easily blocked. These new valves can be retro-fitted to any FlowSyn unit with electrically operated injection valves. Vertical syringe ports mean that syringes can be left in place during a run to make re-priming easier.
Filed Under: Drug Discovery
