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Biogen’s gosuranemab fails in Phase 2 study

By Brian Buntz | June 17, 2021

BiogenBiogen (NSDQ:BIIB) has scrapped its development plans for gosuranemab (BIIB092) after the drug candidate failed to hit the primary endpoint in a Phase 2 trial. 

Biogen’s aducanumab made waves recently, becoming the first Alzheimer’s drug to win FDA approval in recent memory. Not all, however, are happy with that fact. 

Aducanumab is an amyloid beta-protein inhibitor while gosuranemab was an anti-tau antibody. 

In the TANGO Study, gosuranemab did not appear to have a treatment benefit in several measures in the 78-week study. Such measures included the Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-Cog 13), the Alzheimer Disease Cooperative Study Activity of Daily Living (ADCS-ADL), the Mini-Mental State Examination (MMSE) and the Functional Assessment Questionnaire (FAQ). 

Biogen will present the findings from the gosuranemab study at an upcoming medical congress.

The biotech iPierian first developed the antibody, which was initially known as IPN007. Bristol-Myers Squibb acquired rights to the antibody in 2014 when BMS acquired iPierian. Biogen licensed PN007, which it dubbed BIIB092, in 2017. 

BIIB092 had also failed to demonstrate efficacy in the 2019 PASSPORT trial, which had a duration of one year. 


Filed Under: clinical trials, Drug Discovery, Neurological Disease
Tagged With: Aducanumab, Alzheimer's disease, Alzheimer’s, BIIB092, Biogen, Bristol-Myers Squibb, gosuranemab, iPierian, IPN007, PASSPORT, TANGO study, tau
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

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