
“We continue to build and strengthen our intellectual property position, an important element of our overall product strategy,” said Zoran Zdraveski, chief patent counsel, Epizyme. “When issued, this patent will cover claims directed to methods of treating cancer, including non-Hodgkin, follicular and diffuse large B-cell lymphomas, with small molecule EZH2 inhibitors including EPZ-6438.”
Epizyme’s small molecule inhibitor of EZH2, EPZ-6438 (E7438), is currently being developed in a Phase 1/2 clinical trial in patients with advanced solid tumors or relapsed or refractory B-cell lymphoma. In 2014, Epizyme plans to initiate two proof of concept studies with EPZ-6438, pending Phase 1 completion, one in non-Hodgkin lymphoma patients with EZH2 point mutations and one in synovial sarcoma patients. EPZ-6438 is being developed in collaboration with Eisai Inc.
Date: April 24, 2014
Source: Epizyme
Filed Under: Drug Discovery