Triple Quadrupole Mass Spectrometer - Drug Discovery and Development

Shimadzu Scientific Instruments’ LCMS-8040 is a triple quadrupole mass spectrometer, which combines improved ion optics and collision cell technology with ultra-fast technologies to expand the application range and ensure high-sensitivity, high-throughput analysis at lower levels of detection.

The LCMS-8040 features the world’s fastest polarity switching at 15 ms and a high-speed scanning rate of 15,000 µ/sec. The instrument achieves MRM transition speeds up to 555 MRMs per second with UFsweeper II collision cell technology. UFsweeper II features high-speed ion transport technology that maintains sensitivity and suppresses crosstalk, even for high-speed or simultaneous multi-components analyses.

The LCMS-8040 incorporates the UF-Lens ion optics, which integrate two multi-pole RF ion guides, and UFsweeper II technology to provide higher multiple reaction monitoring (MRM) sensitivity. A five-fold increase in sensitivity (reserpine, S/N ratio) has been achieved by improving ion focusing and minimizing ion losses between multi-pole lenses. These improvements also yield higher sensitivity for scan mode measurements. The combination of speed and sensitivity expands the potential range of LC/MS/MS applications and makes the 8040 suitable for qualitative/quantitative analysis.

LabSolutions LCMS software offers a variety of data processing features, including a Quantitation Browser, which processes multiple analytes; and a data browser, which allows users to analyze and compare multiple sets of data in the same window. Users also can optimize MRM parameters with LabSolutions software by utilizing automated flow injection analysis.

Shimadzu provides a variety of method packages to eliminate the need for MRM determination and chromatographic method development. Additionally, the LCMS-8040 features a user-friendly interface and compatibility with LCMS-8030 MRM parameters for easy method transfer.

Shimadzu Scientific Instruments