TTP LabTech’s Acumen eX3 is designed to scan tissue sections mounted on microscope slides. Its large field of view (400mm2) enables the rapid collection of multi-colored fluorescence data from whole sections of tissue at a time. Acumen eX3 provides three different modes of use. Cytometry mode rapidly scans, analyzes, and reports high content information yielding small post-scan file sizes (> 50kB). For more detailed evaluations, TIFF files can be exported and analyzed in batch mode using third-party image processing software.
Cytometry mode may be used to determine regions of interest within larger sections for visual scoring. Validation data comparing the use of cytometric versus image analysis of exported TIFF files (using third-party software) for the determination of mitotic index in tumor sections, has shown that cytometric analysis by Acumen software generated comparable results to those gained by image analysis of “no-threshold” TIFF images using third-party software.
Published in Drug Discovery & Development magazine: Vol. 11, No. 12, December, 2008, p.6.
Filed Under: Drug Discovery