Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Time-Lapse Microscopy

By Drug Discovery Trends Editor | June 10, 2010

zerodriftOlympus has introduced the IX81-ZDC2 Zero Drift microscope system, a motorized inverted microscope with a comprehensive, integrated autofocus solution for investigators doing time-lapse experiments. The IX81-ZDC2 Zero Drift system’s next-generation autofocus system is designed to operate continuously so that it maintains focus even when the events being observed happen very quickly and experiments occur over a short timescale. In addition, the system easily can be set to operate in a discrete, one-shot mode designed to facilitate applications that require maintaining multiple focus positions, such as experiments involving multi-well imaging. The system is optimized for use with total internal reflectance fluorescence (TIRF) and other advanced applications.

The ZDC2 Zero Drift system uses a Class 1 785nm laser diode to locate either the water/glass interface (for oil- or water-immersion objectives) or the air/glass interface (for non-immersion lenses). Samples can be mounted on coverslips, multi-well tissue culture plates, glass-bottom culture dishes or other glass substrates. Working in tandem with MetaMorph® for Olympus software, ZDC2 Zero Drift uses an intermediate lens to focus to the desired z-position (depth) in the sample, automatically maintaining focus for seconds, hours, days or weeks. Using its automated continuous mode, users can easily retain precise focus even after reagents are added.

The IX81-ZDC2 Zero Drift provides the crispest, sharpest, brightest images possible under time-lapse conditions. It can be used with a broad range of objectives including two key high-transmission Olympus TIRF lenses – the APON 60x, 1.49 NA and the UAPON 100x 1.49 NA objectives. ZDC2 Zero Drift also is an excellent choice for keeping focus during multi-modal calcium experiments that employ both TIRF and Fura-2.  In conjunction with the Olympus cell^TIRF illuminator, the system allows simultaneous, high-speed multi-angle TIRF imaging.

Date: June 10, 2010
Source: Olympus 


Filed Under: Drug Discovery

 

Related Articles Read More >

Lokavant’s Spectrum v15 uses AI to cut trial-feasibility modeling from weeks to minutes
Prime time for peptide-based drug discovery 
Why smaller, simpler molecular glues are gaining attention in drug discovery
Glass vial, pipette and woman scientist in laboratory for medical study, research or experiment. Test tube, dropper and professional female person with chemical liquid for pharmaceutical innovation
Unlocking ‘bench-to-bedside’ discoveries requires better data sharing and collaboration
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE