Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • R&D 100 Awards
  • Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50

Stroke Prevention Therapy Is Low Among AF Patients

By Drug Discovery Trends Editor | August 29, 2011

New data shows that one in three patients with atrial fibrillation (AF) who are at high risk for stroke are not being prescribed anticoagulant therapy, particularly vitamin K antagonists (VKA) – medicines known to significantly lower stroke risk.

The findings are from the first cohort of the GARFIELD (Global Anticoagulant Registry in the Field) – a research initiative being conducted by the Thrombosis Research Institute (TRI) to understand the global burden of AF.

The first analysis of cohort one included 9,288 patients newly-diagnosed with AF and with at least one additional risk factor for stroke from 19 countries in the Americas, Europe, Asia, and Asia Pacific.  Of these patients, 81% had a high risk for stroke.

“We know that atrial fibrillation carries a significant stroke risk and anticoagulants can reduce that risk by more that 60 percent; however, GARFIELD data suggest a lower utilization than would be anticipated based on clinical trial evidence and current treatment guidelines,” says Ajay Kakkar, director of the TRI, and professor of surgery, University College London. “Too many patients remain unprotected, and understanding the reasons for this will help in the appropriate adoption of innovative strategies to prevent stroke and improve clinical outcomes.”

The main reason cited for patients not receiving VKAs was “physician choice” (37%); fewer cited reasons such as low stroke risk (13%); excessive bleeding risk (7%) or history of previous bleeding event (2%). Overall 25% of patients were not prescribed an anticoagulant but received an antiplatelet drug such as aspirin alone which has proven less effective in lowering stroke risk in patients at high risk for stroke as an anticoagulant.

Release Date: August 28, 2011
Source: Thrombosis Research Institute 


Filed Under: Drug Discovery

 

Related Articles Read More >

Takeda Pharmaceutical in the Drug Discovery & Development Pharma 50
Takeda’s Takhzyro fares well in pediatric hereditary angioedema study
Novartis in the Pharma 50
Novartis to cut up to 8,000 positions
Gilead Sciences in the Drug Discovery & Development Pharma 50
Gilead resubmits application to FDA for twice-yearly HIV drug lenacapavir
George Floyd mural
How the pandemic and George Floyd made clinical trial diversity a priority

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.

Need Drug Discovery news in a minute?

We Deliver!
Drug Discovery & Development Enewsletters get you caught up on all the mission critical news you need. Sign up today.
Enews Signup
Drug Discovery and Development
  • MASSDEVICE
  • DEVICETALKS
  • Medical Design & Outsourcing
  • MEDICAL TUBING + EXTRUSION
  • MEDTECH 100
  • Medical Design Sourcing
  • Subscribe to our Free E-Newsletter
  • Contact Us
  • About Us
  • Advertise With Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2022 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • R&D 100 Awards
  • Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50