SPR Detection System - Drug Discovery and Development

FUJIFILM Corporation launched the AP-3000 label-free surface plasmon resonance (SPR) detection system for fragment-based lead discovery (FBLD). The AP-3000 is a high-sensitivity SPR biosensor that can detect small fragments with weak binding affinities accurately, reliably, and reproducibly with high throughput, according to FUJIFILM Corporation.

The AP-3000 is capable of the simultaneous measurement of multiple samples (up to six samples), enabling label-free screening of 3,840 samples per day. The system is designed to run all steps of the SPR process unattended.

The system optimizes the injection, flow, and measurement of low volume samples, and reduces the amount of protein and compound needed for analysis. The plastic biosensor can be used up to 400 times, thereby reducing running costs.

Some of the benefits of the system are: high sensitivity, the system can measure the binding level of small molecules as low as 100 Daltons; high throughput, the binding level of 3,840 analytes can be obtained in 24 hours; automatic process, all processes of preparing the materials, immobilizing proteins, injecting compounds, and obtaining binding data are fully automated; and low sample and running costs, technology to inject and circulate small amounts of samples lowers the amount of proteins and compounds being used while plastic biosensors can be used up to 400 times each, reducing running costs, according to the company.