Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Snail Venom Holds Key to Better Diabetes Treatments?

By Walter and Eliza Hall Institute | September 14, 2016

This is a Marine cone snail: conus geographus. (Photo credit: Professor B. Olivera, University of Utah.)

New research has found that venom extracted from a species of marine cone snail could hold the key to developing ‘ultra-fast-acting’ insulins, leading to more efficient therapies for diabetes management.

Researchers from Australia and the US have successfully determined the three-dimensional structure of a cone snail venom insulin, revealing how these highly efficient natural proteins called Con-Ins G1 can operate faster than human insulin.

The teams also discovered that Con-Ins G1 was able bind to human insulin receptors, signifying the potential for its translation into a human therapeutic.

Associate Professor Mike Lawrence from Melbourne’s Walter and Eliza Hall Institute of Medical Research led a collaborative study between the University of Utah, the Monash Institute of Pharmaceutical Sciences, La Trobe University and Flinders University in Australia.

Associate Professor Lawrence, a specialist in the structure of insulins and their receptors, said the teams utilized the Australian Synchrotron to create and analyze the three-dimensional structure of this cone snail venom insulin protein with exciting results.

“We found that cone snail venom insulins work faster than human insulins by avoiding the structural changes that human insulins undergo in order to function—they are essentially primed and ready to bind to their receptors,” Associate Professor Lawrence said.

Associate Professor Lawrence said human insulins could be considered ‘clunky’ by comparison.

“The structure of human insulins contain an extra ‘hinge’ component that has to open before any ‘molecular handshake’ or connection between insulin and receptor can take place.

“By studying the three-dimensional structure of this snail venom insulin we’ve found how to dispense with this ‘hinge’ entirely, which may accelerate the cell signaling process and thus the speed with which the insulin takes effect.” Associate Professor Lawrence said.

Published in Nature Structural and Molecular Biology, the team’s findings build on earlier studies from 2015, when the University of Utah reported that the marine cone snail Conus geographus used an insulin-based venom to trap its prey. Unsuspecting fish prey would swim into the invisible trap and immediately become immobilized in a state of hypoglycemic shock induced by the venom.

Dr. Helena Safavi-Hemami from the University of Utah said it was fascinating to uncover how the cone snail insulin was able to have such a rapid effect on its prey and, furthermore, that the peptide had therapeutic potential in humans. “We were thrilled to find that the principles of cone snail venom insulins could be applied to a human setting,” Safavi-Hemami said.

“Our Flinders University colleagues have shown that the cone snail insulin can ‘switch on’ human insulin cell signaling pathways, meaning the cone snail insulin is able to successfully bind to human receptors,” Safavi-Hemami said.

“The next step in our research, which is already underway, is to apply these findings to the design of new and better treatments for diabetes, giving patients access to faster-acting insulins,” she said.

To read the full press release, click here. 

Follow us on Twitter and Facebook for updates on the latest pharmaceutical and biopharmaceutical manufacturing news! 


Filed Under: Drug Discovery

 

Related Articles Read More >

Sanders, King target DTC pharma ads but the industry worries more about threats to its $2B R&D model
Zoliflodacin wins FDA nod for treatment of gonorrhea
FDA approved ENFLONSIA for the prevention of RSV in Infants
First clinical study results of Dupixent for atopic dermatitis in patients with darker skin tones 
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE