Agilent Technologies Inc., has introduced the Agilent 6150B Series single quadrupole liquid chromatograph/mass spectrometer (LC/MS), a new generation of this workhorse instrument. The 6150B Series has substantially higher sample throughput and delivers unmatched performance in the single quad LC/MS category.
“Many users, such as drug discovery labs, are moving to faster chromatography,” said Wayne Duncan, Agilent single quadrupole LC/MS marketing manager. “This means that their mass specs must keep pace with very sharp, narrow chromatographic peaks lasting less than one second. The Agilent 6150B Series LC/MS is well-matched to the latest fast chromatography systems, enabling labs to run many more samples per day in a very robust way, without any loss of data quality.”
To match the speed of fast chromatography, including ultra highperformance liquid chromatography (UHPLC) such as the Agilent 1290 Infinity platform, the Agilent 6150B Series can scan at 10,000 amu per second, while maintaining exceptional data quality. This is important to confirm identification of the correct compound in the complex reaction mixtures such as those found in drug discovery synthesis.
The Agilent 6150B Series is the first Agilent single quadrupole LC/MS equipped with Agilent Jet Stream Technology, a unique sample inlet design that uses super-heated sheath gas to focus the ion stream entering the mass spec. The benefit is enhanced sensitivity from a stronger signal with lower relative standard deviation at the limit of detection. Agilent Jet Stream Technology has demonstrated the ability to provide efficient ionization for a broader range of compounds than electrospray
ionization or atmospheric pressure chemical ionization alone. This can also increase sample throughput by minimizing the need to rerun samples in multiple ionization modes to look for differences.
The Agilent 6150B Series joins two other single quad LC/MS models in the Agilent lineup: the 6120B, which is the easiest-to-use instrument for applications such as confirming identities of impurities in a QA/QC lab; and the 6130B, which is ideal for quantitative analysis of compounds over a broad range of molecular weight. Each Agilent 6100B Series model can be upgraded to higher levels of performance as needs change, protecting the lab’s investment.
Date: March 2, 2010
Source: Agilent Technologies Inc.
Filed Under: Drug Discovery