Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the research and development of mRNA and microRNA targeted therapies, and Pfizer Inc., announced that the companies have expanded their collaboration directed to the development and commercialization of RNA-targeted medicines using Santaris Pharma A/S Locked Nucleic Acid (LNA) Drug Platform.
Under the terms of the expanded agreement, Pfizer will make a payment of $14 million for access to Santaris Pharma A/S LNA technology for the development of RNA-targeted drugs. Santaris Pharma A/S is eligible to receive milestone payments of up to $600 million as well as royalties on sales of products that may be developed for up to 10 new RNA targets selected by Pfizer.
The newly expanded alliance builds on the original collaboration formed in January 2009 between Santaris Pharma A/S and Wyeth, which was acquired by Pfizer Inc. Under the terms of the original collaboration, Santaris Pharma A/S received an upfront payment of $7 million in cash and Wyeth made a $10 million equity investment in Santaris Pharma A/S. Santaris Pharma A/S continues to be eligible to receive milestones and royalties under the original alliance. Pfizer has advanced several programs under the original collaboration and reached a number of early milestones since the inception of the collaboration.
“The expansion of our collaboration with Santaris Pharma A/S demonstrates our strategic intention to partner with innovative biopharm/biotech companies to explore novel drug design technologies as a potential source for breakthrough therapeutics,” said Mikael Dolsten, President of Worldwide Research and Development at Pfizer. He added, “We have been encouraged by the progress of our oligonucleotide collaboration with Santaris Pharma and are eager to explore this expanded partnership for potential additional LNA-based drug projects.”
The Santaris Pharma A/S LNA Drug Platform is the only RNA technology with both mRNA and microRNA targeted drugs in clinical trials, demonstrating the broad utility of the proprietary platform. The unique combination of small size and high affinity achievable with Santaris Pharma A/S LNA technology allows LNA-based drugs to potently and specifically inhibit RNA targets in different tissues without the need for complex delivery vehicles.
“The expanded alliance with Pfizer is a result of our successful collaboration over the last two years and provides further evidence that our LNA Drug Platform is rapidly becoming the technology-of-choice for partners interested in developing RNA-targeted medicines,” said Soeren Tulstrup, President and CEO of Santaris Pharma A/S. “The LNA Drug Platform is well positioned to deliver viable drug candidates today, and we are excited to expand our relationship with Pfizer to pursue our goal of making RNA-targeted drugs for important diseases a reality.”
RNA-targeted drugs are a promising new class of therapeutics that are enabling scientists to develop drugs to work through targets thought to be inaccessible to small molecules and monoclonal antibodies. Typically, RNA-targeted therapies come in two varieties: single-stranded approaches often referred to as “antisense”; and double-stranded approaches often referred to as “siRNA”. The LNA Drug Platform utilizing Santaris Pharma A/S proprietary single-stranded LNA chemistry may provide the key to delivering on the promise of RNA-targeted therapies today by overcoming the limitation of earlier antisense and siRNA technologies.
Date: January 4, 2011
Source: Santaris Pharma A/S
Filed Under: Drug Discovery
