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Sanofi oncology drug candidate hits roadblock

By Brian Buntz | March 14, 2022

SanofiAmcenestrant, a once-promising investigational optimized oral selective estrogen receptor degrader (SERD) from Sanofi (Nasdaq: SNY), did not meet the primary endpoint in a recent Phase 2 trial focused on advanced or metastatic breast cancer.

Sanofi had previously referred to amcenestrant as a “potentially transformative” product.

Investigators did not identify any new safety signals for the drug candidate in the Phase 2 AMEERA-3 trial.

SNY initially dipped after the news was announced but had stabilized by the middle of the day — up 1.60% to $50.94.

Some 367 patients participated in the open-label study.

Sanofi plans to study amcenestrant in the upcoming AMEERA-5 and AMEERA-6 studies.

“This Phase 2 trial evaluated amcenestrant as a monotherapy in a patient population with advanced disease where limited treatment options remain,” said Dr. John Reed, head of research and development at Sanofi. “While we are disappointed with the AMEERA-3 results, we continue to investigate amcenestrant in patients with earlier stages of breast cancer with different tumor profiles and where different standard of care treatments are used.”

 


Filed Under: Oncology
Tagged With: amcenestrant, Sanofi, selective estrogen receptor degrader, SERD
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

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