Thermo Fisher Scientific Inc. introduced its Mass Spectrometric Immunoassay (MSIA) pipette tips, a collection of immunoaffinity sample preparation products. Robust MSIA technology delivers a simplified way to enrich target proteins for downstream mass spectrometric analysis. MSIA pipette tips provide scientists with an easier immunoaffinity approach that yields better and more reproducible quantification results. From sample preparation and quantification to data analysis, top-down mass spectrometry-based quantitative proteomic workflow is simplified with the automated MSIA immunoaffinity technology.
MSIA tips feature a 300 µL pipette tip embedded with a proprietary, highly porous immunoaffinity column that provides increased sensitivity with improved reproducibility and sample throughput. Benefits include:
• Enhanced antibody/antigen-binding kinetics that allow enrichment down to very low levels (femtomoles) for downstream mass spectrometric protein/peptide quantification;
• Improved signal-to-noise ratios due to increased specificity and target recovery as compared to conventional bead-based methods;
• Fast and flexible sample throughput with manual multichannel or fully automated 96-well processing in less than 30 minutes;
• Customizable assay that meets different biomarker research needs.
The MSIA D.A.R.T.’s (Disposable Automation Research Tips) are compatible with the Thermo Scientific Versette automated liquid handler providing immuno-enrichment processing in 96-well format. In addition, the new Thermo Scientific Finnpipette Novus i 8 and 12-channel electronic pipettes (for immuno-precipitation) and adjustable pipette stand are specifically designed to work with MSIA protocols where high sample throughput is not required.
Filed Under: Drug Discovery