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Regenxbio inks deal with AbbVie to pursue development of RGX-314

By Brian Buntz | November 9, 2021

RegenxbioRegenxbio (NSDQ:RGNX) has closed a license agreement with AbbVie (NYSE:ABBV) to develop RGX-314, a vascular endothelial growth factor inhibitor.

The drug has been the focus of Phase 2 and Phase 3 trials exploring its potential in wet age-related macular degeneration (AMD) and diabetic retinopathy.

AbbVie will make an upfront payment to Regenxbio of $370 million and could pay an additional $1.38 billion if the drug candidate meets proposed development, regulatory and commercial milestones.

In the agreement, Regenxbio will focus on overseeing the completion of ongoing trials related to the RGX-314. The two companies will partner and split the cost of additional studies related to the drug candidate.

The two companies intend to perform an additional pivotal trial testing subretinal delivery to treat wet AMD and future trials.

AbbVie plans on leading clinical development and commercialization of the drug.

In October, Regenxbio released positive initial data from an ongoing Phase 2 trial focused on RGX-314. That study is testing the drug candidate’s potential to treat diabetic retinopathy without center-involved diabetic macular edema.


Filed Under: clinical trials, Drug Discovery, Ophthalmology
Tagged With: AbbVie, AMD, diabetic retinopathy, Regenxbio, RGX-314, vascular endothelial growth factor inhibitor, wet age-related macular degeneration
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

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