Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Pfizer And BioDuro Collaboration Leads To Shelf-Stable Reagent

By BioDuro LLC | March 19, 2018

BioDuro LLC, a life science research and development organization, has announced AISF ([4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride), a convenient, shelf-stable, crystalline reagent for the synthesis of fluorosulfates and sulfamoyl fluorides. AISF was developed through a research collaboration with Pfizer Inc.

While fluorosulfates have immense potential applications, from chemical biology to polymer chemistry, the currently utilized method of synthesis relies on the use of sulfuryl fluoride gas. Because sulfuryl fluoride gas is a colorless, odorless, and toxic gas that requires specialized equipment and additional safety precautions when using, this potentially valuable functional group has previously not been fully evaluated or broadly adopted.

“This breakthrough is just one example of what deeply committed and engaged scientists can achieve in a collaborative environment,” said Cyrus K. Mirsaidi, president and CEO, BioDuro. “The creation of AISF and its development into a commercially viable, and environmentally safe product, is a result of a collaboration between the Pfizer and BioDuro chemistry teams, and one that I look forward to continuing as we seek to address new challenges.”

Three key attributes were sought for a solid reagent that could be an alternative to sulfuryl fluoride gas: (1) the reagent must demonstrate comparable or improved reactivity to sulfuryl fluoride gas; (2) it must be a crystalline, shelf-stable and easily manipulated solid; and (3) it must be readily accessible for manufacturing on a large scale from commercially available starting materials.

AISF is a stable, crystalline solid that allows for a user-friendly fluorosulfonation reaction set-up, and it has excellent substrate scope. The reagent is easily manipulated in an open atmosphere and is stable at ambient temperature as either a solid or in solution, over a prolonged period of time.

“We are proud of this collaboration and our ability to address a common challenge in pharmaceutical preparation, delivering a solution that has a positive impact for both scientists and the environment,” said Charlotte Allerton, head of medicine design, Pfizer.

(Source: BioDuro LLC)


Filed Under: Drug Discovery

 

Related Articles Read More >

Swissmedic approves first malaria treatment for infants
Korean team reports all-in-one cancer nanomedicine in pre-clinical studies
Nektar’s Phase 2b atopic dermatitis win triggers 1,746% analyst target surge, but legal tussle with ex-partner Lilly could complicate path forward
Dupixent approved to treat bullous pemphigoid
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE