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Pardes Biosciences shares interim Phase 1 data on oral COVID-19 antiviral

By Brian Buntz | February 16, 2022

Pardes BiosciencesPardes Biosciences (NSDQ:PRDS) said its PBI-0451 twice-daily COVID-19 pill candidate had favorable tolerability and good oral bioavailability, based on interim data from an ongoing Phase 1 trial.

The company also said the drug candidate lacked clinically significant drug-drug interactions.

“We’re very encouraged by the safety profile and bioavailability profile we’re seeing to date,” Brian Kearney, chief development officer at Pardes Bio, said in an investor call.

Pardes Biosciences also noted that, in the interim results, PBI-0451 administered twice-daily maintained pharmacokinetics exposures anticipated to deliver strong antiviral activity against SARS-CoV-2.

The company plans on launching a Phase 2/3 study in the middle of 2022.

Two oral antivirals have won U.S. emergency use authorization (EUA). FDA authorized Paxlovid from Pfizer (NYSE:PFE) and molnupiravir from Merck (NYSE: MRK) and its partner Ridgeback Biotherapeutics in late December.

PRDS shares ticked down 8.70% to $10.29 today.


Filed Under: clinical trials, Drug Discovery, Infectious Disease
Tagged With: coronavirus, covid-19, Pardes Biosciences, PBI-0451, SARS-CoV-2
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

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