Continue to Site

Drug Discovery and Development

Oxford Gene Technology expands next-generation sequencing line

By |

Oxford Gene Technology

[Image from Oxford Gene Technology]

Oxford Gene Technology (OGT) has expanded its SureSeq line of next-generation sequencing (NGS) panels to detect genetic variants associated with breast and ovarian cancer and myeloid disorders.

One of the offerings is a myeloid panel that can detect abnormalities in 70 genes associated with a range of diseases, including acute myeloid leukemia, myelodysplastic syndrome and myeloproliferative neoplasms. The panel can detect clinically relevant single nucleotide variants and insertion-deletion mutations (indels) with a 1% variant allele frequency, according to the company.

“One of the key facets of our SureSeq NGS panel offering is our customisation programme, SureSeq myPanel, in this we collaborate with our customers to rapidly generate the content that they desire, often this is at the forefront of discovery and not always commercially available,” said Emma Shipstone, executive vice president marketing at OGT. “Once there is community consensus on desired content we have the ability to bring panel content previously developed and optimized to a broader market.”

In addition, a 7-gene breast and ovarian cancer panel targets genes commonly tied to breast and ovarian cancer, such as BRCA1 and BRCA2. The panel also can detect copy number variation, the disparity in the number of copies of genes among individuals tied to several cancers, OGT said. The full interrogation of BRCA genes conventionally has required multiple tests to identify indels, single nucleotide variants and copy number variations. The SureSeq breast cancer panel can identify such variations in a single test, according to the manufacturer.

The breast and ovarian cancer panel also may identify mutations related to ataxia-telangiectasia mutated (ATM) genes, tumor protein P53, checkpoint kinase 2 (CHEK2), partner and localizer of BRCA2 (PALB2) in addition to phosphatase and tensin homolog (PTEN). The panel can also detect copy number variations in single exons in addition to full gene deletions or duplications in these genes, the company said.

Filed Under: Drug Discovery, Genomics/Proteomics, Oncology
Tagged With: , , , ,
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

Tell Us What You Think!

Related Articles Read More >

Search Drug Discovery & Development