Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Niraparib promoted long-term progression-free survival benefit in Phase 3 advanced ovarian cancer study 

By Brian Buntz | September 9, 2022

GSKBrentford, UK–headquartered GSK (LSE/NYSE:GSK) reported long-term data from the phase 3 PRIMA study indicating that the PARP inhibitor Zejula (niraparib) promoted a sustained and clinically meaningful progression-free survival (PFS) benefit in ovarian cancer patients.

The survival benefit was evident across biomarker subgroups, including BRCAm, HRd and HRp.

Patients in the HRd subgroup had a 48% reduction of progression or death compared to placebo.

The estimated probability of no progressive disease or death at four years in the broader population was 24% for niraparib compared to 14% for placebo.

GSK plans to present the updated efficacy analysis data on September 11 at the (European Society for Medical Oncology) ESMO Annual Meeting in Paris.

GSK noted in a news release that the overall survival data are “not yet mature based on the prespecified analysis plan.”

The study tested niraparib as maintenance therapy in first-line ovarian cancer patients who had a response to platinum-based chemotherapy.

Waltham, Massachusetts–based Tesaro initially developed niraparib, which won FDA approval for recurrent ovarian cancer in 2017. Niraparib was the first PARP inhibitor to win FDA approval without requiring BRCA mutation or another biomarker testing.

Niraparib won Fast Track designation for recurrent platinum-sensitive ovarian, fallopian tube, or primary peritoneal cancer in 2016.

GSK announced an agreement to acquire Tesaro in late 2018.

Niraparib has scored additional indications for ovarian cancer in 2019 and 2020.

“Patients can face a high risk of recurrence when diagnosed with late-stage ovarian cancer,” said Hesham Abdullah, senior vice president, global head of oncology development at GSK, in a news release. “The updated analysis of this study shows that Zejula can help patients potentially achieve a long-term remission.”

GSK noted that the study uncovered no new safety signals and that the safety profile of niraparib was in line with the primary analysis.

GSK shares were up 1% to $31.83 in early afternoon trading.


Filed Under: Oncology
Tagged With: GSK, niraparib, ovarian cancer, Zejula
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

Related Articles Read More >

New treatment paradigms in oncology: Highlights from the ASCO 2025 annual meeting
Korean team reports all-in-one cancer nanomedicine in pre-clinical studies
As some biotechs cut, Genmab unveils striking new site near Princeton
OS Therapies announces favorable FDA feedback on external control arm strategy for osteosarcoma drug
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE