Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Molecule in Japanese Cypress Tree Leaves Could Pave Way for New Anemia Therapies

By Boston Children's Hospital | May 16, 2017

Photo via: https://midatlanticgardening.com/plant-profile-hinoki-false-cypress-chamaecyparis-obtusa-nana-gracilis/

Researchers find key molecule that could lead to new therapies for anemia.

Researchers find key molecule that could lead to new therapies for anemia and other iron disorders

“Without iron, life itself wouldn’t be feasible,” says Barry Paw, MD, PhD. “Iron transport is very important because of the role it plays in oxygen transport in blood, key metabolic processes and DNA replication.”

New findings reported in Science by a multi-institutional team, including researchers from University of Illinois, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Brigham and Women’s Hospital and Northeastern University, could impact a whole slew of iron disorders, ranging from iron-deficiency anemia to iron-overload liver disease.

The team has discovered a small molecule found naturally in Japanese cypress tree leaves, hinokitiol, can bypass iron disorders in animals. Paw, co-senior author on the new Sciencepaper and physician at Dana-Farber/Boston Children’s, and members of his lab demonstrated that hinokitiol can successfully reverse iron deficiency and iron overload in zebrafish disease models.

As a result, hinokitiol has big therapeutic potential.

Iron Regulation Is Essential to Health

Although iron is crucial to many aspects of health, it can’t transport itself without the help of the body’s iron-transporting proteins. Many human diseases of iron deficiency or overload result from hereditary or acquired loss of the protein function that is responsible ferrying iron across cellular membranes, subcellular compartments and mitochondrial membranes.

“Like most things in life, too much or too little of a good thing is bad for you; the body seeks homeostasis and balance,” says Paw.

“Amazingly, we observed in zebrafish that hinokitiol can bind and transport iron inside or out of cell membranes to where it is needed most.”

For example, iron is a necessary co-factor in the body’s production of hemoglobin, a protein that carries oxygen in the blood of vertebrates. But if iron-transporting proteins are absent, iron can’t get across cell membranes and inside the cells’ mitochondria, blocking an essential step of hemoglobin production.

“Red blood cells are the number one type of tissue in the body that need iron, so if iron-transporting proteins are missing, anemia can result,” says Paw. “Iron-deficiency anemia is the most common nutritional problem in the world.”

On the flip side, it’s not good if too much iron builds up inside cells either. Iron overload can cause tissue damage, DNA damage and life-threatening organ dysfunction across the heart, liver and pancreas. This can be caused by a hereditary lack of iron-transporting proteins or from receiving frequent blood transfusions, which are often necessary over the course of treatment for many different medical conditions.

A Totally New Approach to Treating Iron-Transport Disorders

“If you’re sick because you have too much protein function, in many cases we can do something about it. But if you’re sick because you’re missing a protein that does an essential function, we struggle to do anything other than treat the symptoms. It’s a huge unmet medical need,” said the paper’s co-senior author Martin Burke, MD, PhD, who led team members from University of Illinois.

Burke’s team initially found that hinokitiol could transport iron across cell membranes in vitro before reaching out to Paw and other collaborators to test its efficacy in animal models.

A stain reveals hemoglobin production in a healthy zebrafish (left), an anemic zebrafish (middle) and an anemic zebrafish treated with hinokitiol (right).

Paw and collaborators observed that hinokitiol molecules can bind to iron atoms and move them across cell membranes and into/out of mitochondria, despite an absence of the native proteins that would usually carry out these functions.

“If there is a genetic error, cell membranes won’t open for iron to come across,” says Paw. “But when you administer hinokitiol, it combines with iron and ferries it into, within or out of the cells and mitochondria where iron is needed.

“Therefore, it’s a very interesting small molecule that has a lot of therapeutic potential!” Paw concludes.

(Source: EurekAlert!)

(Lead image source: Mid-Atlantic Gardening.)

Follow us on Twitter and Facebook for updates on the latest pharmaceutical and biopharmaceutical manufacturing news!


Filed Under: Drug Discovery

 

Related Articles Read More >

Lokavant’s Spectrum v15 uses AI to cut trial-feasibility modeling from weeks to minutes
Prime time for peptide-based drug discovery 
Why smaller, simpler molecular glues are gaining attention in drug discovery
Glass vial, pipette and woman scientist in laboratory for medical study, research or experiment. Test tube, dropper and professional female person with chemical liquid for pharmaceutical innovation
Unlocking ‘bench-to-bedside’ discoveries requires better data sharing and collaboration
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE