Thermo Fisher Scientific’s LTQ Orbitrap hybrid series of mass spectrometers are now available with electron transfer dissociation (ETD) and matrix-assisted laser desorption/ionization (MALDI) capabilities. The LTQ Orbitrap XL ETD is the only ETD instrument with both high resolution and accurate mass, enabling definitive protein characterization during mass spectrometry (MS). The new MALDI LTQ Orbitrap series simplifies the analysis of whole tissue, biological, and polymer samples by eliminating sample preparation.
ETD technology enables highly sensitive, post-translational modification analyses. Combined with the power of the LTQ Orbitrap XL, ETD completes the most advanced proteomics platform available by offering three complementary fragmentation techniques in one instrument. It can be used for definitive protein/peptide characterization, post-translational modification (PTM) analysis (especially phosphorylation) and top-down or middle-down sequencing of proteins and peptides.
This article was published in Drug Discovery & Development magazine: Vol. 11, No. 4, April, 2008, pp. 48.
Filed Under: Drug Discovery