Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Johnson & Johnson gearing up for COVID-19 vaccine data announcement

By Brian Buntz | January 27, 2021

Johnson & JohnsonJohnson & Johnson (NYSE:JNJ) is poised to announce new data related to its Ad26 COVID-19 vaccine early next week. 

In an earnings call yesterday, management hinted that they expect results from the vaccine to be positive but stopped short at revealing details.

“We think it’s very important to follow the data — to follow the science,” said JNJ CEO Alex Gorsky after declining to answer a question related to COVID-19 variants and vaccine efficacy until the official data announcement.

The company published interim phase 1/2a data from its vaccine study in the New England Journal of Medicine earlier this month.

[Related: Johnson & Johnson pharma sales drive Street-beating Q4 results]

If the company’s adenovirus-based vaccine performs in the same league as those from Moderna (NSDQ:MRNA) and Pfizer (NYSE:PFE), Ad26 could play a vital role in stemming the COVID-19 crisis. Unlike competitors’ vaccines, Ad26 could be offered in a single dose, potentially simplifying mass-vaccination efforts. 

Former Operation Warp Speed chief Moncef Slaoui suggested that Ad26 vaccine efficacy could be in the 80% range. Slaoui had not seen JNJ trial data when making that estimate.

The company “hoped” and “planned” for 70% efficacy, Chief Scientific Officer Paul Stoffels told Time, but the vaccine could potentially offer greater efficacy, he added, citing encouraging early-stage trial data. 

UBS analysts estimate that vaccine efficacy from a single dose of the Ad26 would be 65% to 75%. The firm based that rough calculation on JNJ’s phase 1 data and results from AstraZeneca’s (LON:AZN) adenovirus-vectored vaccine, whose efficacy ranged from 62% to 90% in a Phase 3 trial depending on the dosing regimen of the two-dose vaccine.

UBS estimates that an efficacy level of 80% or higher could drive the company’s stock higher, assuming the clinical trial data is robust. “If efficacy is below 80%, there could be some weakness depending on the magnitude and cleanliness of the data,” UBS said in a briefing note. 

The potential for new COVID-19 variants to reduce the Johnson & Johnson vaccine’s efficacy could potentially weaken its standing. The approximately 95% efficacy levels of the Pfizer and Moderna mRNA vaccines against early SARS-CoV-2 strains will likely translate to significant protection against the B.1.351 and P.1 variants, for example. “However, this is worrisome for vaccines that are not as potent in inducing neutralizing antibodies as the two mRNA vaccines,” said Florian Krammer, a vaccine researcher at the Icahn School of Medicine at Mount Sinai, in an interview with Science.

In any event, the Ad26 vaccine efficacy could be greater with two doses. Johnson & Johnson is enrolling a dual-dose trial. It anticipates data from that study later this year. 


Filed Under: clinical trials, Drug Discovery, Drug Discovery and Development, Infectious Disease
Tagged With: Ad26, clinical trials, coronavirus, covid-19, COVID-19 vaccine, COVID-19 vaccine trial, Johnson & Johnson
 

About The Author

Brian Buntz

As the pharma and biotech editor at WTWH Media, Brian has almost two decades of experience in B2B media, with a focus on healthcare and technology. While he has long maintained a keen interest in AI, more recently Brian has made making data analysis a central focus, and is exploring tools ranging from NLP and clustering to predictive analytics.

Throughout his 18-year tenure, Brian has covered an array of life science topics, including clinical trials, medical devices, and drug discovery and development. Prior to WTWH, he held the title of content director at Informa, where he focused on topics such as connected devices, cybersecurity, AI and Industry 4.0. A dedicated decade at UBM saw Brian providing in-depth coverage of the medical device sector. Engage with Brian on LinkedIn or drop him an email at bbuntz@wtwhmedia.com.

Related Articles Read More >

Swissmedic approves first malaria treatment for infants
Korean team reports all-in-one cancer nanomedicine in pre-clinical studies
Nektar’s Phase 2b atopic dermatitis win triggers 1,746% analyst target surge, but legal tussle with ex-partner Lilly could complicate path forward
Dupixent approved to treat bullous pemphigoid
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE