Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Orphan Drugs
  • R&D 100 Awards

Intravacc touts preclinical, non-human results for COVID-19 nasal spray vaccine

By Sean Whooley | April 7, 2021

IntravaccIntravacc is today touting positive pre-clinical results of its SARS-CoV-2 nasal spray vaccine candidate in non-human subjects.

Bilthoven, Netherlands-based Intravacc’s SARS-CoV-2 outer membrane vesicle (OMV)-based recombinant spike protein (rSp) nasal spray candidate was observed in four groups of mice and four groups of hamsters, all of which received two intranasal immunizations on day one and day 21, according to a news release.

Get the full story at our sister site, Drug Delivery Business News.

Tell Us What You Think! Cancel reply

You must be logged in to post a comment.

Related Articles Read More >

Lab image
What is needed to develop disease-modifying therapies for Parkinson’s and Alzheimer’s 
Johnson & Johnson
Feds halt J&J COVID-19 vaccine due to blood clot concern
pharmaceuticals
Analyzing FDA guidance on DDI studies for therapeutic proteins
Pfizer-BioNTech
Pfizer asks FDA to authorize its COVID-19 vaccine for younger teens

Intravacc touts preclinical, non-human results for COVID-19 nasal spray vaccine

By Sean Whooley | April 7, 2021

IntravaccIntravacc is today touting positive pre-clinical results of its SARS-CoV-2 nasal spray vaccine candidate in non-human subjects.

Bilthoven, Netherlands-based Intravacc’s SARS-CoV-2 outer membrane vesicle (OMV)-based recombinant spike protein (rSp) nasal spray candidate was observed in four groups of mice and four groups of hamsters, all of which received two intranasal immunizations on day one and day 21, according to a news release.

One group of each animal received a vaccine based on OMVs mixed with rSp and the other a vaccine based on OMVs coupled to rSp based on Intravacc’s proprietary OMV click technology. Control animals received only OMVs or only rSp, respectively.

In the mice that received the CovOMV and CovOMV click vaccines, 30% and 90% virus-neutralizing antibodies were detected, respectively. Both candidate vaccines produced neutralizing antibodies in all hamsters, but the level in the click group was slightly higher compared to the other.

Intranasal vaccination with both OMV-rSp vaccine candidates resulted in complete protection after challenge, with zero lung lesions detected by histopathology, seven days after hamsters were challenged. All hamsters that received the vaccines showed reduced systemic weight loss after challenge, while unvaccinated animals or those in the control lost more than 10% of their bodyweight.

“We are very pleased with this pre-clinical data of our intranasal SARS-CoV-2 candidate vaccine,” Intravacc CEO Dr. Jan Groen said in the release. “This allows us to move quickly towards an in human combined phase I and II clinical trial. Based on historical scientific- and clinical data generated at Intravacc, I am convinced that we are well-positioned for the further development of this vaccine. This and previous data clearly demonstrate the value of our OMV-vaccine technology for future development of other preventive and therapeutic vaccines.”

Related Articles Read More >

Johnson & Johnson
Feds halt J&J COVID-19 vaccine due to blood clot concern
Intravacc
Intravacc touts preclinical, non-human results for COVID-19 nasal spray vaccine
Pfizer-BioNTech vaccine
EU allows Pfizer/BioNTech COVID-19 vaccine to be stored at higher temperatures
Janssen
FDA approves oral multiple sclerosis treatment from J&J’s Janssen unit

DeviceTalks Tuesdays

DeviceTalks Tuesdays

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.

Need Drug Discovery news in a minute?

We Deliver!
Drug Discovery & Development Enewsletters get you caught up on all the mission critical news you need. Sign up today.
Enews Signup

R&D Twitter

Tweets by @RandDWorld
Drug Discovery and Development
  • Enews Signup
  • Contact Us
  • R&D World
  • Pharmaceutical Processing
  • Drug Delivery Business News

Copyright © 2021 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Orphan Drugs
  • R&D 100 Awards