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Inhaled Product Testing

By Drug Discovery Trends Editor | March 7, 2010

Copley Scientific DUSACopley Scientific will introduce the company’s new DUSA shaker at Respiratory Drug Delivery 2010 on April 25-29 in Orlando, Fla. The small-footprint unit automates the rinsing of DUSA collection tubes, increasing productivity and enhancing the reproducibility of drug recovery, especially for low solubility formulations. It also reduces the risk of operator exposure to repetitive strain injury.

Dose uniformity testing is mandatory for all inhaled products to confirm consistency from batch to batch and across the product lifetime. Individual shots are recovered from a DUSA collection tube by thorough rinsing, post-testing, with an appropriate solvent. This manually-intensive agitation process is prone to inter- and intra-operator variability and any failure to adequately wet all internal walls compromises drug recovery and the integrity of the results.

The DUSA shaker holds up to 21 MDI or 12 DPI collection tubes on a series of rollers, subjecting them to a controlled lateral shake and rolling action; shaking frequency and duration can both be set according to test requirements. This process ensures that all internal surfaces are adequately wetted and that agitation is performed with a smooth and yet vigorous action. The unit can be supplied with supporting IQ/OQ documentation. It has a footprint of 570 mm by 610 mm.

Copley Scientific 


Filed Under: Drug Discovery

 

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