Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE

Hops Extract Studied to Prevent Breast Cancer

By University of Illinois at Chicago | July 13, 2016

An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC/NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago.

Natural botanical dietary supplements such as hops have become increasingly popular among women for postmenopausal symptoms, as they are perceived as a safer alternative to hormone therapy, which has been linked to increased risk of breast cancer. However, the efficacy and potential toxicity of botanicals are still being studied.

Researchers led by Judy Bolton, professor and head of medicinal chemistry and pharmacognosy in the UIC College of Pharmacy, applied hops extract to two different breast cell lines to see if they would affect estrogen metabolism, a key mechanism in breast cancer. One compound, 6-prenylnarigenin, or 6-PN, increased a detoxification pathway in the cells that has been linked to a lower risk for breast cancer.

“We need to further explore this possibility, but our results suggest that 6-PN could have anti-cancer effects,” Bolton said.

In addition to 6-PN, Bolton and her colleagues studied 8-prenylnarigenin (8-PN), isoxanthohumol (IX) and xanthohumol (XH) for their effects on estrogen metabolism in breast cells. According to Bolton, 8-PN showed only a slight increase of metabolism in breast cells, while the other two compounds did not have significant effects in either cell line.

Breast cancer is one of the most commonly diagnosed cancers in women in the U.S.; about one in eight U.S. women will develop invasive breast cancer over their lifetime. An estimated 246,660 new cases of invasive breast cancer and 61,000 new cases of non-invasive breast cancer are expected in women in the U.S. this year, according to the American Cancer Society.

The incidence of breast cancer began decreasing in 2000, after increasing during the previous two decades. Just from 2002 to 2003, the incidence declined by 7 percent. Some think the drop was partly due to reduced use of hormone replacement therapy, or HRT, after results of the Women’s Health Initiative suggested a link between HRT and increased breast cancer risk. Estrogen exposure has long been linked with postmenopausal breast cancer risk, especially since the 2002 report, Bolton said.


Filed Under: Drug Discovery

 

Related Articles Read More >

Korean team reports all-in-one cancer nanomedicine in pre-clinical studies
Nektar’s Phase 2b atopic dermatitis win triggers 1,746% analyst target surge, but legal tussle with ex-partner Lilly could complicate path forward
Dupixent approved to treat bullous pemphigoid
EVEREST lead investigator on why Dupixent sets a new bar for treating coexisting CRSwNP and asthma
“ddd
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest news and trends happening now in the drug discovery and development industry.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
Drug Discovery and Development
  • MassDevice
  • DeviceTalks
  • Medtech100 Index
  • Medical Design Sourcing
  • Medical Design & Outsourcing
  • Medical Tubing + Extrusion
  • Subscribe to our E-Newsletter
  • Contact Us
  • About Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2025 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Women in Pharma and Biotech
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • Resources
    • Video features
    • Podcast
    • Voices
    • Views
    • Webinars
  • Pharma 50
    • 2025 Pharma 50
    • 2024 Pharma 50
    • 2023 Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50
  • Advertise
  • SUBSCRIBE