The CellKey 384 System from MDS Analytical Technologies is a high-throughput 384-well instrument that utilizes the award-winning, label-free, cellular-measurement technology of the original 96-well CellKey System. The system’s four-fold increase in throughput enables researchers to accelerate the screening of endogenous targets and reduce the cost-per-well by using less cells and reagents.
The CellKey 384 System was created to enable label-free, real-time analysis of cell-surface receptor activity in a single comprehensive assay format independent of the signaling pathway. Researchers can now perform primary screens on larger libraries since the 384-well format is more conducive to high-throughput screening environments than previous 96-well systems which targeted therapeutic and secondary screening. The system is used to accelerate the development of drug therapies for inflammation, oncology, and cardiovascular disease. The label-free feature removes the time-consuming and often costly step of trying to optimize the assays using tags or dyes.
With an integrated onboard fluidics head, the CellKey 384 System enables compound dispensing to all 384 wells, while simultaneously measuring the kinetic cellular responses. Additionally, an incorporated tip wash system extends unattended throughput during automation, and reduces costs related to pipette tip consumables.
Filed Under: Drug Discovery