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Thermo Fisher Scientific Inc. introduces an application note demonstrating how the Thermo Scientific NanoDrop 3300 enables cancer researchers to study DNA methylation events and polyamine induced DNA G-quadruplex formations by microvolume fluorometry. The fluorospectrometer allows researchers to perform fluorescence measurements simply, quickly and cost-effectively, making the instrument a valuable tool for cancer research and biomedical research applications.
This new application note reviews methods in the current literature where the fluorospectrometer enables scientists to investigate complex DNA structures within the field of cancer research. The application note provides an insight into the benefits of using fluorescence spectroscopy for proof of concept experimentation of DNA methylation detection assays, as well as DNA G-quadruplex analysis.
Fluorescence spectroscopy methodologies are also aiding the targeting of and delivery to cancer cells in vivo to correct defects, inhibit growth and induce apoptosis. In addition, the technique provides excellent sensitivity and specificity for researchers working in this field. The patented “cuvette-less” sample retention system employed by the fluorospectrometer enables fluorescent measurements using as little as one microlitre sample volume. The fluorospectrometer is also capable of analyzing multiple emission profiles from a single sample. In addition, the easy-to-use instrument has a small footprint, taking up minimal space in the laboratory.
Filed Under: Drug Discovery
