The FlowSyn range of integrated, flow reactor systems from Uniqsis Ltd. has been designed to handle a range of applications from homogeneous single reactions to complex, multi-reagent reactions. Optional gas addition, microwave, and low temperature and binary pump (4-channel) modules further enhance the operational versatility of the system.
Flow chemistry in micro-reactors has many advantages over batch processing notably better reproducibility and scalability, improved yields and fewer problems with unstable intermediates or exothermic reactions.
The system is available with the widest range of reactors (2 – 60 ml) in a choice of inert materials including stainless steel, Hastelloy, PFA, PTFE or copper. Reactions requiring the use of strong acids such as nitric acid (nitrations) and organometallic bases such as butyl lithium are possible. A unique 2- or 3-channel borosilicate glass mixer chip reactor enables the system to undertake high throughput applications, fast mixing dependent reactions, and highly exothermic reactions requiring temperature control.
Two high pressure pumps operating at up to 100 bar (1,400 psi) deliver reagents, via a mixer, into electrically heated flow reactors. Back pressure regulators pressurize the system, allowing solvents to be superheated to a maximum of 260 C.
Reaction outputs from the FlowSyn system can be fractionated or optimized at steady state, after which the system automatically flushes itself ready for the next experiment. The process is controlled using an integrated control interface.
Filed Under: Drug Discovery