Drug Discovery and Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • R&D 100 Awards
  • Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50

Early Biomarker Defined in Alzheimer’s Disease

By Drug Discovery Trends Editor | March 4, 2016

A multicenter study led by Christian Haass and Michael Ewers of Ludwig-Maximilians-Universitaet (LMU) in Munich has identified a biomarker associated with the activation of an innate immune response to neural damage during early stages of Alzheimer’s disease.

Alzheimer’s disease results from the accumulation in the brain of protein deposits that are toxic to nerve cells. The deposits themselves are largely comprised of insoluble aggregates of so-called beta-amyloid peptides – short fragments cleaved from a protein found on nerve-cell membranes – and they begin to form decades before any overt symptoms of dementia emerge. Now research teams led by Christian Haass, who holds the Chair of Metabolic Biochemistry at LMU and is the speaker of the German Center for Neurodegenerative Diseases (DZNE) in Munich, and Professor Michael Ewers of the Institute for Stroke and Dementia Research (ISD) at Munich University Medical Center, now report that the concentration of a specific segment of the protein TREM2 in cerebrospinal fluid (CSF) is significantly elevated in early stages of Alzheimer’s disease. “Our findings indicate that TREM2 plays an important role in the progression of Alzheimer’s, and perhaps even other forms of dementia. It appears to be part of a defense mechanism that involves phagocytic cells that eliminate damaged nerve cells and toxic protein deposits, such as those made up of beta-amyloid peptides,” said Haass. The new study has now been published in the journal EMBO Molecular Medicine.

TREM2 is a cell-surface receptor that is essential for the function of specialized phagocytic cells called microglia, which are found only in the brain. Microglial cells serve as an arm of the innate immune system and act as the brain’s waste disposal squad, recognizing and destroying cell debris and other types of toxic particulate material. The detection by Haass, Ewers and colleagues of increased concentrations of a soluble fragment of TREM2 in the CSF of patients with mild symptoms of Alzheimer’s disease forges a further link between the protein and the neurodegenerative disorder. The same researchers had previously shown that mutations that affect TREM2 function also reduce the ability of microglia to clear amyloid aggregates and damaged cells.

An informative and versatile marker

In their latest work, the LMU team studied over 400 Alzheimer’s patients who showed cognitive defects of varying severity, and compared them with age-matched controls. Biochemical analyses of samples of CSF revealed that patients who exhibited mild cognitive deficits had the highest concentrations of a particular fragment of the TREM2 protein found in the study. The amounts detected in patients with advanced Alzheimer’s disease were significantly lower. “This correlates with the level of activity of the microglial cells, which falls off as the condition progresses. This in turn presumably means that less beta-amyloid and cell debris can be cleared away,” Haass points out. “We therefore believe that this biomarker provides us with a way to assess the capacity of innate immune cells in the brain to degrade and dispose toxic material.”

At the current stage it is still unclear whether the changes in the concentration of the TREM2 fragment in the CSF is a cause or a consequence of disease progression. However, the researchers favor the idea that the early increase in the level of TREM2 is attributable to the activation of microglia in response to initial signs of damage to the nerve cells in the brain. “Our results indicate that the alterations in TREM2 reflect physiological changes that occur at an early stage in the development of Alzheimer’s dementia. This makes TREM2 interesting from a therapeutic perspective,” said Michael Ewers.

The new biomarker could also make it possible to monitor the efficacy of novel anti-inflammatory approaches for treatment of Alzheimer’s disease. In addition, measurements of the levels of TREM2 in the CSF could help to define the most effective window for early interventions to combat or control the disorder. The LMU researchers propose a long-term longitudinal study, in which the concentration of TREM2 in CSF samples from individuals with mutations known to be linked to familial Alzheimer’s disease is determined at regular intervals under controlled conditions.

Source: LMU


Filed Under: Drug Discovery

 

Related Articles Read More >

Roche in Drug Discovery & Development Pharma 50
Roche’s bispecific antibody Lunsumio wins priority review from FDA for non-Hodgkin lymphoma
Tiffany Hurd
CB Therapeutics biz dev lead sees upside for psychedelics in mental health and beyond
Pharmacovigilance
A new era of pharmacovigilance: Worldwide master key for drug safety monitoring
Takeda Pharmaceutical in the Drug Discovery & Development Pharma 50
Takeda’s Takhzyro fares well in pediatric hereditary angioedema study

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.

Need Drug Discovery news in a minute?

We Deliver!
Drug Discovery & Development Enewsletters get you caught up on all the mission critical news you need. Sign up today.
Enews Signup
Drug Discovery and Development
  • MASSDEVICE
  • DEVICETALKS
  • Medical Design & Outsourcing
  • MEDICAL TUBING + EXTRUSION
  • MEDTECH 100
  • Medical Design Sourcing
  • Subscribe to our Free E-Newsletter
  • Contact Us
  • About Us
  • Advertise With Us
  • R&D World
  • Drug Delivery Business News
  • Pharmaceutical Processing World

Copyright © 2022 WTWH Media LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media
Privacy Policy | Advertising | About Us

Search Drug Discovery & Development

  • Home Drug Discovery and Development
  • Drug Discovery
  • Genomics/Proteomics
  • Oncology
  • Neurological Disease
  • Infectious Disease
  • R&D 100 Awards
  • Pharma 50
    • 2022 Pharma 50
    • 2021 Pharma 50