Daiichi Sankyo Company, Limited, announced that it has filed for approval in Japan to manufacture and market AMG 162 (denosumab), a gene recombinant drug for bone disorders stemming from bone metastases.
Denosumab is the world’s first fully human monoclonal antibody to target RANK ligand, an essential mediator of osteoclast formation. Daiichi Sankyo has been working on denosumab since 2007, when it acquired the rights from Amgen Inc. to develop and market this antibody in Japan.
In addition, Daiichi Sankyo is conducting a Phase 3 clinical trial for denosumab to treat osteoporosis in Japan.
In denosumab, Daiichi Sankyo aims to benefit patients, their families, and medical professionals by augmenting the few available therapeutic alternatives for treating disorders stemming from cancer-related bone metastases with a new and effective treatment option.
Date: August 24, 2010
Source: Daiichi Sankyo Company, Limited
Filed Under: Drug Discovery