A new handheld device that combines CRISPR technology with graphene-based electronic transistors can rapidly detect specific genetic mutations. Researchers from the University of California, Berkeley and the Keck Graduate Institute of The Claremont Colleges have created the CRISPR-Chip device that can in just a few minutes diagnose genetic diseases or evaluate the accuracy of other…
Research Suggests New Drug Targets for Osteoporosis
For Infection-fighting Cells, a Guideline for Expanding the Troops
Gene Identified That Increases Risk of Antibiotic Reaction
Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin. Routine testing for this gene could improve patient safety and reduce unnecessary avoidance of other antibiotics, they reported in the Journal of Allergy and Clinical Immunology.…
New Strategy Improves Efficiency of CRISPR-Cas9 Genome Editing
Genomics Researchers Say ‘Junk’ DNA Key to Advancing Medicine
New Protein Could Deliver Next Gene-Editing Tool
While CRISPR Cas9 remains a mainstay in the genomics world, researchers have now found a much smaller protein called CasX that could be used for gene editing. In 2017, a research team from the University of California Berkeley discovered in some of the world’s smallest bacteria a protein similar to Cas9 but substantially smaller, which…
In Prenatal Testing, ‘Genomics’ Sometimes Sees What Genetic Tests Can’t
New Mutations Causing Inherited Deaf-Blindness Have Been Discovered
A team of scientists from Sechenov First Moscow State Medical University (MSMU) together with their colleagues from leading scientific centers of Moscow and India described a number of genetic mutations causing Usher syndrome (inherited deaf-blindness). They found previously unstudied unique mutations in investigated DNA regions. The results of the study were published in the Ophthalmic Geneticsjournal.…
Whole Genome Sequencing Method May Speed Personalized Treatment of Drug-Resistant Infections
Orchard Therapeutics to Build New Gene Therapy Manufacturing Facility in California
CRISPR Method for Conditional Gene Regulation
A team of engineers at the University of Delaware has developed a method to use CRISPR/Cas9 technology to set off a cascade of activities in cells, a phenomenon known as conditional gene regulation. Their method, described in the journal Nature Chemical Biology, introduces a new functionality to CRISPR, one of today’s most-talked-about technologies. Gene editing…
CRISPR Gene Editing Will Find Applications in Plastic and Reconstructive Surgery
Breakthrough: Promising New Genetic Target for Immunotherapy
Following the 2018 Nobel Prize for Medicine, global attention is now more than ever turned toward the promise of immunotherapy in oncology. An international team’s work has shed new light on a molecule called TIM-3 that might play a key role in the regulation of the immune response. Scientists and physicians from the Research Institute…
Novel Combination Therapy Promotes Wound Healing
By incorporating a gene-suppressing drug into an over-the-counter gel, researchers at Albert Einstein College of Medicine and their colleagues cut healing time by half and significantly improved healing outcomes compared to control treatments. Results from the combination therapy, which was tested in mice, were published online today in Advances in Wound Care. “Not only did wound…
New CRISPR Tool Opens Up More of the Genome for Editing
The genome editing system CRISPR has become a hugely important tool in medical research, and could ultimately have a significant impact in fields such as agriculture, bioenergy, and food security. The targeting system can travel to different points on the genome, guided by a short sequence of RNA, where a DNA-cutting enzyme known as Cas9 then…
Novel DNA Vaccine Design Offers Broad Protection Against Influenza-A H3N2
Researchers Modify CRISPR to Reorganize Genome
Researchers at Stanford University have reworked CRISPR-Cas9 gene-editing technology to manipulate the genome in three-dimensional space, allowing them to ferry genetic snippets to different locations in a cell’s nucleus. The new technique, dubbed CRISPR-genome organization or simply CRISPR-GO, uses a modified CRISPR protein to reorganize the genome in three dimensions. If CRISPR is like molecular…
A New Way to Manufacture Small Batches of Biopharmaceuticals on Demand
CRISPR Helps Produce Bigger, Healthier Tomatoes
Decoding the Structure of an RNA-Based CRISPR System
Next-Generation Sequencing: The Need for Quality Control
CRISPR Screen Identifies Gene That Helps Cells Resist West Nile, Zika Viruses
Gilead Sciences and Precision BioSciences Collaborate to Develop Therapies Against Hepatitis B Virus Using Genome Editing
Gilead Sciences and Precision BioSciences announced today that the companies have entered into a strategic collaboration to develop therapies targeting the in vivo elimination of hepatitis B virus (HBV) with Precision’s proprietary genome editing platform, ARCUS. An estimated 257 million people are living with HBV infection around the world. Current HBV treatments suppress HBV viral replication but…