CRISPR Helps Produce Bigger, Healthier Tomatoes
Decoding the Structure of an RNA-Based CRISPR System
Next-Generation Sequencing: The Need for Quality Control
CRISPR Screen Identifies Gene That Helps Cells Resist West Nile, Zika Viruses
Gilead Sciences and Precision BioSciences Collaborate to Develop Therapies Against Hepatitis B Virus Using Genome Editing
Gilead Sciences and Precision BioSciences announced today that the companies have entered into a strategic collaboration to develop therapies targeting the in vivo elimination of hepatitis B virus (HBV) with Precision’s proprietary genome editing platform, ARCUS. An estimated 257 million people are living with HBV infection around the world. Current HBV treatments suppress HBV viral replication but…
Hspgo: More Than Just a Chaperone
Molecular Hopper Can Move Individual DNA Strands
A research team from the University of Oxford has developed a molecular hopper that is small enough to be able to move single strands of DNA through a protein nanotube. The device works by making and breaking in sequence simple chemical bonds that attach it to a nanoscale track that can be turned on, off…
CRISPR Halts Duchenne Muscular Dystrophy Progression in Dogs
Scientists for the first time have used CRISPR gene editing to halt the progression of Duchenne muscular dystrophy (DMD) in a large mammal, according to a study by UT Southwestern that provides a strong indication that a lifesaving treatment may be in the pipeline. The research published in Science documents unprecedented improvement in the muscle…
Predicting How Splicing Errors Impact Disease Risk
No one knows how many times in a day, or even an hour, the trillions of cells in our body need to make proteins. But we do know that it’s going on all the time, on a massive scale. We also know that every time this happens, an editing process takes place in the cell…
New Method Grows Brain Cells From Stem Cells Quickly and Efficiently
CasPER: A New Method For Diversification of Enzymes
A new study published in the Metabolic Engineering Journal describes a method based on CRISPR/Cas9, which enables flexible engineering of essential and nonessential enzymes without additional engineering. This could be of great importance for various aspects including the development of bio-based production of pharmaceuticals, food additives, fuels and cosmetics. “When having a production strain this will make…
Approval of First ‘RNA Interference’ Drug – Why the Excitement?
Small interfering RNA sounds like something from a science fiction novel rather than a revolutionary type of medicine. But this odd-sounding new drug offers a novel strategy for treating disease by targeting the root cause rather than just the symptoms. This is an exciting approach because it enhances the effectiveness of the treatment and reduces…
Progress Toward Personalized Medicine
New CRISPR-SKIP Technique Can More Specifically Target Genes
Injection of Novel Gene Therapy Vector Prolonged Survival in Mouse Model of Pompe Disease
Stem Cell Research for Cystic Fibrosis Leaps Forward
Study Elucidates Epigenetic Mechanisms Behind Autoimmune Diseases
A group of researchers at the University of São Paulo (USP) in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimune diseases such as autoimmune polyglandular syndrome type 1 (APS-1) and type 1 diabetes. The autoimmune regulator or “Aire” gene…
Researchers Discover CRISPR/Cas9 Gene Editing Tools Could Cause Unforeseen Mutations
Scientists Sharpen the Edges of Cancer Chemotherapy With CRISPR
New Informatics Tool Makes the Most of Genomic Data
Biochemists Discover Cause of Genome Editing Failures With Hyped CRISPR System
Researchers from the University of Illinois at Chicago are the first to describe why CRISPR gene editing sometimes fails to work, and how the process can be made to be much more efficient. CRISPR is a gene-editing tool that allows scientists to cut out unwanted genes or genetic material from DNA, and sometimes add a…
