Caliper Life Sciences, Inc. introduced Bioware Ultra cell lines, a range of ultra bright light producing tumor cell lines created specifically for in vivo imaging applications. Bioware Ultra cell lines are 10 to 100 times brighter than cell lines created using traditional methods, which allows researchers to detect a single cancer cell in an animal via non-invasive in vivo imaging.
The seven cell lines covering a range of cancer models, including breast, colorectal, lung and prostate as well as lymphoma.
By tagging a tumor with the gene for luciferase, the tumor can produce light that can be monitored using Caliper’s IVIS imaging systems. As the disease progresses and reacts to specific compounds, researchers can measure tumor growth and evaluate the efficacy of compounds in real time. This ability to track disease progression in vivo offers a more conclusive understanding of how potential drugs will react in and impact humans.
Increasing the brightness of tumor producing cell lines significantly improves researchers’ ability to monitor early tumor behavior and detect micrometastases sooner. Caliper’s Bioware Ultra light producing cell lines incorporate the enhanced luc2 gene from Promega. The luc2 gene, an optimized version of luciferase for expression in mammalian cells, creates intensified visible light allowing more sensitive non-invasive detection of cells in vivo.
Filed Under: Drug Discovery