The prestigious 2008 R&D 100 Award has been given to three of Bruker Corporation’s products. The magnetic resonance imaging (MRI) CyroProbe and 1.7 mm MicroCyroProbe, along with the SMARTX2S automated chemical X-ray crystallography system were distinguished—by an independent judging panel and editors of R&D Magazine—to be one of the 100 most technologically-significant products introduced into the marketplace over the past year.
“The winning of an R&D 100 Award provides a mark of excellence known to industry, government, and academia as proof that the product is one of the most innovative ideas of the year,” explains Martha Walz, R&D Magazine editor-in-chief.
The MRI CryoProbe delivers an increase in sensitivity of approximately a factor of 2.5x in small animal in vivo MRI. This enables very high 3D isotropic spatial resolution down to 60 µm, or alternatively an increase in acquisition speed by more than a factor of 5x compared to conventional room temperature MRI RF coils. In combination with high magnetic fields, the instrument enables new pre-clinical neuroscience studies with functional MRI (fMRI).
The MicroCryoProbe, which features sensitivity on an active volume of only 30 microliters, offers an increase in mass sensitivity of more than an order of magnitude. It is suitable of any nuclear magnetic resonance (NMR) analysis with limited sample amounts, e.g. natural products, drug metabolites, isolated low abundance proteins, peptides or small molecules, or difficult-to-express proteins.
The SMART X2S for the first time allows inorganic and organic chemists to produce atomic resolution, 3D molecular structures in their own laboratories quickly and easily at the touch of a button. The device takes small molecule structure determination to the next level of convenience by automating the previously difficult aspects of X-ray structure determination, from sample loading and alignment through data collection all the way to the mathematical structure solution, structure verification and report generation.
Dr. Michael Ruf, Director of Marketing for Chemical Crystallography and Development Manager for the SMART X2S stated: “Winning the R&D 100 award is a tremendous recognition for our development team.”
Filed Under: Drug Discovery