The LabChip EZ Reader from Caliper Life Sciences is a benchtop instrument that facilitates kinase testing and other enzyme screening and profiling. LabChip assays are separations-based, so the quality of results exceeds what is achievable in homogenous, well-based assays. The LabChip EZ Reader runs kinase and enzymatic assays with a 4-Sipper microfluidics chip.
The LabChip EZ Reader analyzes kinase activity by ‘sipping’ stopped reactions from 96- or 384-well microtitre plates. Caliper’s Mobility Shift Assay technology is designed for in vitro enzyme assays aimed at the drug discovery process. It provides direct measurement of substrate and product, rapid assay development, and real-time kinetic reads.
The EZ Reader platform can run kinase profiling with the Caliper Profiler Pro Kits, which consist of matched pairs of 384-well kinase assay and substrate plates. The assay plates each contain 24 different kinases, pre-dispensed and frozen. The substrate plates contain the appropriate fluorescently labeled peptides and ATP.
The LabChip EZ Reader II provides the option to run assays with either a 4-Sipper or a 12-Sipper microfluidics chip.
Published in Drug Discovery & Development magazine: Vol. 12, No. 4, April, 2009, p.18.
Filed Under: Drug Discovery
