Twenty-five years have passed since the publication of the first work on solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) as a system for delivering drugs. So the European Journal of Pharmaceutics and Biopharmaceutics has prepared a special edition for which it asked the PharmaNanoGene group of the UPV/EHU-University of the Basque Country to…
Lipid Nanoparticles for Gene Therapy
Lipid nanoparticles (SLNs and NLCs) are regarded as highly promising systems for delivering nucleic acids in gene therapy. Until now, viral systems have been the most effective method for delivering genetic matter but they pose significant safety problems. “Non-viral vectors, including SLNs and NLCs, are less effective but much safer even though their effectiveness has…