
Candidate for Universal Flu Vaccine Protects Against Multiple Strains
A universal flu vaccine that protects people against most influenza strains is one step closer to reality, with a study from the Perelman School of Medicine at the University of Pennsylvania. The candidate vaccine, described in Nature Communications this week, elicited a strong antibody response to a structure on the surface of flu viruses, called the hemagglutinin…
First Mouse Model to Mimic Lung Disease Could Speed Discovery of More Effective Treatments
Approach Could Limit Toxicity of CAR T Therapy in Acute Myeloid Leukemia
Humira Does Not Improve Aortic Vascular Inflammation in Psoriasis Patients
An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation – a key marker of future risk of major cardiovascular events – unlike other antibodies that target different aspects of the immune system. Researchers from the Perelman…
T-Cell Biomarker Predicts Which CLL Patients Will Respond to CAR T Cell Therapy
Penn Medicine researchers may have found the reason why some patients with advanced chronic lymphocytic leukemia (CLL) don’t respond to chimeric antigen receptor (CAR) T cell therapy, and the answer is tied to how primed patients’ immune systems are before the therapy is administered. While 80 percent of patients with advanced acute lymphoblastic leukemia (ALL)…