A group of scientists in Denmark is trying to get one step ahead in the battle against antibiotic resistance. Today, many disease-causing bacteria acquire resistance genes, which make antibiotic treatment ineffective. Especially, one gene, CTX-M-15, encoding an extended spectrum beta-lactamase (ESBL) can lead to resistance in E. coli causing urinary tract infections. The team of researchers at…
CasPER: A New Method For Diversification of Enzymes
A new study published in the Metabolic Engineering Journal describes a method based on CRISPR/Cas9, which enables flexible engineering of essential and nonessential enzymes without additional engineering. This could be of great importance for various aspects including the development of bio-based production of pharmaceuticals, food additives, fuels and cosmetics. “When having a production strain this will make…