Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research…
During HIV Infection, Antibody Can Block B Cells From Fighting Pathogens
NIAID Scientists Create 3D Structure of 1918 Influenza Virus-Like Particles
Virus-like particles (VLPs) are protein-based structures that mimic viruses and bind to antibodies. Because VLPs are not infectious, they show considerable promise as vaccine platforms for many viral diseases, including influenza. Realizing that fine details about influenza VLPs were scant, a team of researchers who specialize in visualizing molecular structures developed a 3D model based…
Modified Experimental Vaccine Protects Monkeys from Deadly Malaria
FDA-Approved Drug Helps Treat Rare Immunologic Disease, Study Finds
Adding the injectable drug mepolizumab to standard treatment for eosinophilic granulomatosis with polyangiitis (EGPA), a rare immunologic disease, significantly improved clinical outcomes among participants in an advanced clinical trial, scientists report. The study was funded jointly by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and…
Malaria Treatment Fails in Cambodia
New findings inform new WHO treatment guidelines that reinstate former first-line therapy. New findings from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), confirm dihydroartemisinin-piperaquine, the first-line treatment for Plasmodium falciparum malaria infection in Cambodia, has failed in certain provinces due to parasite resistance to artemisinin and piperaquine.…