
Study Triggers Change in WHO Treatment Guidelines for Lymphatic Filariasis
Researchers from Case Western Reserve University School of Medicine have shown that a single “cocktail” of three pill-based anti-parasite medications is significantly more effective at killing microscopic larval worms in people diagnosed with lymphatic filariasis, commonly known as elephantiasis, than other standard two-drug combinations previously used in the global effort to eliminate this infectious disease.…
New Images Show Serotonin-activating its Receptor for First Time
Serotonin (3A) receptors are common drug targets in the treatment of pain, gastrointestinal dysfunctions, and mood disorders yet little is known about their three-dimensional structure. Details about serotonin receptor structures could provide important clues to designing better drugs with less side effects. Now, a team of researchers from Case Western Reserve University School of Medicine…
Researchers Cure Drug-resistant Infections without Antibiotics
Biochemists, microbiologists, drug discovery experts and infectious disease doctors have teamed up in a new study that shows antibiotics are not always necessary to cure sepsis in mice. Instead of killing causative bacteria with antibiotics, researchers treated infected mice with molecules that block toxin formation in bacteria. Every treated mouse survived. The breakthrough study, published…
New Drug Target Identified for Heart Failure Patients
Researchers Pinpoint New Drug Target for Heart Failure Patients
Novel Antibiotic Combination Therapy Overcomes Deadly Drug-Resistant Bacteria
Computerized Tissue Image Analysis Reveals Underlying Genomics of ER+ Breast Cancer
The number of tubules in tumors may predict which women with estrogen receptor positive (ER+) breast cancer will benefit from hormone therapy alone and which require chemotherapy, researchers at Case Western Reserve University have found. Tubules represent the tumor’s vasculature, providing tumors with oxygen and nutrition. The more of them there are, the more likely…
Researchers Restore Drug Sensitivity in Breast Cancer Tumors
Drug Candidate Shrinks Tumor When Delivered by Plant Virus Nanoparticle
In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo. Triple-negative breast cancer tumors of mice treated with the phenanthriplatin -carrying…