
Countermeasures to Oncology Trial Failure: 5 Smarter Approaches to Trial Design and Analysis
Oncology trials fail far too frequently, and often for similar reasons. We have observed oncology studies fail frequently due to five prevalent issues: assumptions that undermined a trial’s design; inadequate patient selection criteria; problematic phase 2 trials; over-interpretation of subgroup analyses; and optimistic selection of a non-inferiority margin. This article will review these common issues…